Analyzing protein structure and function using ancestral gene reconstruction
about
Epistatic adaptive evolution of human color visionExploiting models of molecular evolution to efficiently direct protein engineeringExperimental macroevolutionProtein stability: computation, sequence statistics, and new experimental methodsMechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid ReceptorConversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closingConservation of Protein Structure over Four Billion YearsX-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding InterfaceVestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone ReceptorAn atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenasesPlant synthetic biology for molecular engineering of signalling and developmentCollective dynamics differentiates functional divergence in protein evolutionPhyloBot: A Web Portal for Automated Phylogenetics, Ancestral Sequence Reconstruction, and Exploration of Mutational TrajectoriesAncestral ReconstructionA simple method for studying the molecular mechanisms of ultraviolet and violet reception in vertebratesRapid bursts and slow declines: on the possible evolutionary trajectories of enzymesHow old is my gene?Synthetic biology of phenotypic adaptation in vertebrates: the next frontierA branch-heterogeneous model of protein evolution for efficient inference of ancestral sequencesEvolution of increased complexity in a molecular machineTracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptorClassification of protein functional surfaces using structural characteristics.Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.Convergence of Domain Architecture, Structure, and Ligand Affinity in Animal and Plant RNA-Binding Proteins.Structure of an enzyme-derived phosphoprotein recognition domainEvolutionary biochemistry: revealing the historical and physical causes of protein properties.Thermodynamic system drift in protein evolution.Evolution of oligomeric state through allosteric pathways that mimic ligand bindingEvolution of an ancient protein function involved in organized multicellularity in animals.The thermostability and specificity of ancient proteins.Evolutionary trend toward kinetic stability in the folding trajectory of RNases H.Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees.Subdomain interactions foster the design of two protein pairs with ∼80% sequence identity but different folds.Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation diversityMechanistic insight into the functional transition of the enzyme guanylate kinase induced by a single mutationReconstructed ancestral Myo-inositol-3-phosphate synthases indicate that ancestors of the Thermococcales and Thermotoga species were more thermophilic than their descendants.The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae.Protein variants form a system of networks: microdiversity of IMP metallo-beta-lactamases.Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism
P2860
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P2860
Analyzing protein structure and function using ancestral gene reconstruction
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Analyzing protein structure and function using ancestral gene reconstruction
@ast
Analyzing protein structure and function using ancestral gene reconstruction
@en
Analyzing protein structure and function using ancestral gene reconstruction
@nl
type
label
Analyzing protein structure and function using ancestral gene reconstruction
@ast
Analyzing protein structure and function using ancestral gene reconstruction
@en
Analyzing protein structure and function using ancestral gene reconstruction
@nl
prefLabel
Analyzing protein structure and function using ancestral gene reconstruction
@ast
Analyzing protein structure and function using ancestral gene reconstruction
@en
Analyzing protein structure and function using ancestral gene reconstruction
@nl
P2860
P3181
P1476
Analyzing protein structure and function using ancestral gene reconstruction
@en
P2093
Joseph W Thornton
Michael J Harms
P2860
P3181
P356
10.1016/J.SBI.2010.03.005
P407
P577
2010-06-01T00:00:00Z