Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation
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SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathwayE3 ligase Nedd4 promotes axon branching by downregulating PTENUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responseThe Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligasePhenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female miceExosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesisHECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activityPTEN at a glance.MC1R is a potent regulator of PTEN after UV exposure in melanocytesEnzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 LigasesSHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN.Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localizationNedd4 branches out.SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer.PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.
P2860
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P2860
Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crucial role of the C-terminus ...... ubiquitination and degradation
@ast
Crucial role of the C-terminus ...... ubiquitination and degradation
@en
Crucial role of the C-terminus ...... ubiquitination and degradation
@nl
type
label
Crucial role of the C-terminus ...... ubiquitination and degradation
@ast
Crucial role of the C-terminus ...... ubiquitination and degradation
@en
Crucial role of the C-terminus ...... ubiquitination and degradation
@nl
prefLabel
Crucial role of the C-terminus ...... ubiquitination and degradation
@ast
Crucial role of the C-terminus ...... ubiquitination and degradation
@en
Crucial role of the C-terminus ...... ubiquitination and degradation
@nl
P2093
P356
P1433
P1476
Crucial role of the C-terminus ...... ubiquitination and degradation
@en
P2093
Guochang Huang
Junru Wang
Xinjiang Wang
Xuejun Jiang
P356
10.1042/BJ20080674
P407
P577
2008-09-01T00:00:00Z