Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
about
Rational approaches to improving selectivity in drug designUnique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 ProteaseEnzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavirEffect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and DarunavirAmprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clustersThe L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic ContactsNovel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 ProteaseInhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatinStructures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open FlapsCarbamylation of N-Terminal ProlineQuantitative predictions of binding free energy changes in drug-resistant influenza neuraminidaseDetecting and understanding combinatorial mutation patterns responsible for HIV drug resistanceTransition states of native and drug-resistant HIV-1 protease are the same.Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.HIV-1 Protease: Structural Perspectives on Drug ResistanceMolecular Basis for Drug Resistance in HIV-1 ProteaseConserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.Evolution toward small molecule inhibitor resistance affects native enzyme function and stability, generating acarbose-insensitive cyclodextrin glucanotransferase variants.A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.Understanding the basis of I50V-induced affinity decrease in HIV-1 protease via molecular dynamics simulations using polarized force field.HIV-1 protease function and structure studies with the simplicial neighborhood analysis of protein packing method.Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to human immunodeficiency virus protease inhibitors and impair viral replication.Accessory mutations maintain stability in drug-resistant HIV-1 protease.
P2860
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P2860
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Kinetic, stability, and struct ...... mutations L24I, I50V, and G73S
@nl
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@ast
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@en
type
label
Kinetic, stability, and struct ...... mutations L24I, I50V, and G73S
@nl
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@ast
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@en
prefLabel
Kinetic, stability, and struct ...... mutations L24I, I50V, and G73S
@nl
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@ast
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@en
P2093
P2860
P1476
Kinetic, stability, and struct ...... utations L24I, I50V, and G73S.
@en
P2093
Fengling Liu
Irene T Weber
John M Louis
Peter I Boross
Robert W Harrison
Yuan-Fang Wang
P2860
P304
P356
10.1016/J.JMB.2005.09.095
P407
P577
2005-10-21T00:00:00Z