Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
about
Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNAHuman immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathwayPathogenesis of human immunodeficiency virus infectionClass II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 moleculeHuman immunodeficiency virus infection is efficiently mediated by a glycolipid-anchored form of CD4.CD4-T-cell antigen receptor complexes on human leukemia T cells.Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 (gp120), which impairs thioredoxin-driven CD4 dimerizationChanges in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo.Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15Human immunodeficiency virus-infected adherent cell-derived inhibitory factor (p29) inhibits normal T cell proliferation through decreased expression of high affinity interleukin-2 receptors and production of interleukin-2The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule.Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma.HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis.Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Induction of high-titer neutralizing antibodies, using hybrid human immunodeficiency virus V3-Ty viruslike particles in a clinically relevant adjuvantPoliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 1.Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in cocultured lymphocytes.HIV-induced changes in T cell signaling pathwaysAn idiotypic network model of AIDS immunopathogenesis.The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cellsHIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.Analysis of the basis of resistance and susceptibility of CD4+ T cells to human immunodeficiency virus (HIV)-gp120 induced anergy.
P2860
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P2860
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
description
1988 nî lūn-bûn
@nan
1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@ast
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@en
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@nl
type
label
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@ast
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@en
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@nl
prefLabel
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@ast
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@en
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@nl
P2093
P1476
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
@en
P2093
B P Sleckman
D C Diamond
J L Greenstein
S J Burakoff
P304
P407
P577
1988-12-01T00:00:00Z