The heparanome and regulation of cell function: structures, functions and challenges
about
Heparan sulfate and heparin interactions with proteinsTransport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfateSelectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix.FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancerFibroblast growth factors as tissue repair and regeneration therapeutics.A systems biology approach for the investigation of the heparin/heparan sulfate interactomeFell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.Identification of heparin-binding sites in proteins by selective labeling.Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.Heparan sulfate 3-O-sulfation: a rare modification in search of a function.Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains.Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides.Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor.Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.Heparan sulfate proteoglycans.D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars.SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.Age-related changes in rat myocardium involve altered capacities of glycosaminoglycans to potentiate growth factor functions and heparan sulfate-altered sulfationIn silico analyses of heparin binding proteins expression in human periodontal tissuesHeparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification.The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues.Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificityDifferential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation.Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling.Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tractNetwork based meta-analysis prediction of microenvironmental relays involved in stemness of human embryonic stem cells.A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra.DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling.Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cellsHeparan sulfate phage display antibodies identify distinct epitopes with complex binding characteristics: insights into protein binding specificitiesDetermining the anti-coagulant-independent anti-cancer effects of heparin.Roles of heparan sulfate sulfation in dentinogenesisThe Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles.
P2860
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P2860
The heparanome and regulation of cell function: structures, functions and challenges
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The heparanome and regulation of cell function: structures, functions and challenges
@ast
The heparanome and regulation of cell function: structures, functions and challenges
@en
The heparanome and regulation of cell function: structures, functions and challenges
@nl
type
label
The heparanome and regulation of cell function: structures, functions and challenges
@ast
The heparanome and regulation of cell function: structures, functions and challenges
@en
The heparanome and regulation of cell function: structures, functions and challenges
@nl
prefLabel
The heparanome and regulation of cell function: structures, functions and challenges
@ast
The heparanome and regulation of cell function: structures, functions and challenges
@en
The heparanome and regulation of cell function: structures, functions and challenges
@nl
P2093
P1476
The heparanome and regulation of cell function: structures, functions and challenges
@en
P2093
Alessandro Ori
David Garth Fernig
Mark Charles Wilkinson
P304
P407
P577
2008-05-01T00:00:00Z