HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
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HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via NefNano-zymography Using Laser-Scanning Confocal Microscopy Unmasks Proteolytic Activity of Cell-Derived Microparticles.Biogenesis and Function of T Cell-Derived ExosomesExosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism.Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells.Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1.Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1.Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated VasculitisHIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV InfectionThe Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex.Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target?Rho'ing in and out of cells: viral interactions with Rho GTPase signalingTetraspanins in extracellular vesicle formation and function.Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4(+) T lymphocytes and reactivation of the HIV-1 reservoir.Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.Biogenesis and Functions of Exosomes and Extracellular Vesicles.Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation.Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression.Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection.Control of ADAM17 activity by regulation of its cellular localisationThe Multifaceted Functions of Exosomes in Health and Disease: An Overview.Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA.HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
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P2860
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
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2013 nî lūn-bûn
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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2013 թվականի փետրվարին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@ast
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@en
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
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type
label
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@ast
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@en
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@nl
prefLabel
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@ast
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@en
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@nl
P2093
P50
P3181
P1433
P1476
HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases
@en
P2093
Andreas S Baur
Florian S Dreyer
Gerold Schuler
Ian C D Johnston
Jung-Hyun Lee
Kirsten Krätzel
Mathias Lichtenheld
Reinhard Zeidler
Sebastian Wittki
Tanja Bräu
P304
P3181
P356
10.1016/J.MOLCEL.2012.12.004
P407
P50
P577
2013-02-21T00:00:00Z