M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity - Wikidata - awgldk - TriplyDB

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

http://www.wikidata.org/entity/Q28284646

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Dominant-negative effect of truncated mannose 6-phosphate/insulin-like growth factor II receptor species in cancer Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma Targeting the insulin-like growth factor pathway in hepatocellular carcinoma Insulin-like growth factor system in cancer: novel targeted therapies Mannose 6-phosphate receptors: new twists in the tale Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes Environmental epigenomics and disease susceptibility Insulin and insulin-like growth factor signalling in neoplasia Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer.Genomic imprinting: implications for human disease.A patient with Simpson-Golabi-Behmel syndrome and hepatocellular carcinoma.Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid.Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.Imprinted genes as potential genetic and epigenetic toxicologic targets The IGF axis and hepatocarcinogenesis.Cancer gene discovery in hepatocellular carcinoma Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1-24.1.Biology of transforming growth factor beta in hepatocarcinogenesis.The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets.Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance Molecular aspects of hepatic carcinogenesis.Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype Antagonists of growth hormone-releasing hormone inhibit the growth of U-87MG human glioblastoma in nude mice.Monitoring microarray-based gene expression profile changes in hepatocellular carcinoma Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?Expression of the insulin-like growth factors and their receptors in adenocarcinoma of the colon Keys to the hidden treasures of the mannose 6-phosphate/insulin-like growth factor 2 receptor.Tissue-specific inactivation of murine M6P/IGF2R.Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation.Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis.Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling.

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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

http://www.wikidata.org/entity/Q28284646

description

1995 nî lūn-bûn

@nan

1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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name

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@ast

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@en

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@nl

type

label

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@ast

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@en

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@nl

prefLabel

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@ast

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@en

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@nl

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P1433

Nature Genetics

P1476

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

@en

P2093

A T De Souza

http://www.w3.org/2001/XMLSchema#string

G R Hankins

http://www.w3.org/2001/XMLSchema#string

M K Washington

http://www.w3.org/2001/XMLSchema#string

R L Jirtle

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T C Orton

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P2860

Splicing of messenger RNA precursors

Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors.

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.

The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization.

Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing.

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.

Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor.

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis.

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

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P304

447-9

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scholarly article

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10.1038/NG1295-447

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4

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11

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1995-12-01T00:00:00Z

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7493029

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