The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?
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A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareNeuroprotective Sirtuin ratio reversed by ApoE4Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4JDisulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosisIdentification of small molecules enhancing autophagic function from drug network analysis.Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition.Discovery of drug mode of action and drug repositioning from transcriptional responses.Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis.Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway.Disulfiram/copper-disulfiram Damages Multiple Protein Degradation and Turnover Pathways and Cytotoxicity is Enhanced by Metformin in Oesophageal Squamous Cell Carcinoma Cell Lines.Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-AzaindolesRegulation rewiring analysis reveals mutual regulation between STAT1 and miR-155-5p in tumor immunosurveillance in seven major cancers.Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment ScaleDisulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells.The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells.Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspectsDisulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2.Proteasome inhibitor treatment in alcoholic liver disease.How could a drug used to treat alcoholism also be effective against glioblastoma?Repurposing disulfiram for cancer therapy via targeted nanotechnology through enhanced tumor mass penetration and disassembly.
P2860
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P2860
The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@ast
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@en
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@nl
type
label
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@ast
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@en
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@nl
altLabel
The value of proteasome inhibition in cancer
@en
prefLabel
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@ast
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@en
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@nl
P1433
P1476
The value of proteasome inhibition in cancer
@en
The value of proteasome inhibi ...... a novel proteasome inhibitor?
@en
P2093
Boris Cvek
Zdenek Dvorak
P356
10.1016/J.DRUDIS.2008.05.003
P407
P577
2008-08-01T00:00:00Z