Primary structure and biological activity of a novel human neurotrophic factor
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Neurotrophin 3 is a mitogen for cultured neural crest cellstrkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificitiesCloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteinsHigh resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptorsBinding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkCCloning and expression of human ciliary neurotrophic factorNeurotrophic factors and neurologic disease.Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney.Neurotrophins are key mediators of the myelination program in the peripheral nervous system.An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes.Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and ChorioamnionitisThe trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3Calcineurin-NFAT Signaling and Neurotrophins Control Transformation of Myosin Heavy Chain Isoforms in Rat Soleus Muscle in Response to Aerobic Treadmill Training.Differential effects of NGF and NT-3 on embryonic trigeminal axon growth patterns.Neurotrophin 3 stimulates the differentiation of motoneurons from avian neural tube progenitor cellsN-methyl-D-aspartate and TrkB receptor activation in cerebellar granule cells: an in vitro model of preconditioning to stimulate intrinsic survival pathways in neurons.An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth.Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiationNeurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo.Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervationFormation of the thalamocortical projection regulated differentially by BDNF- and NT-3-mediated signaling.Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.Coexpression of neurotrophins and their receptors in neurons of the central nervous system.Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.Expression and function of TRK-B and BDNF in human neuroblastomasPathophysiological mechanisms for actions of the neurotrophins.Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies.Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment.Nerve growth factor in the anterior pituitary: localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism.The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.Alteration of NH2-terminal residues of nerve growth factor affects activity and Trk binding without affecting stability or conformation.
P2860
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P2860
Primary structure and biological activity of a novel human neurotrophic factor
description
1990 nî lūn-bûn
@nan
1990 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Primary structure and biological activity of a novel human neurotrophic factor
@ast
Primary structure and biological activity of a novel human neurotrophic factor
@en
Primary structure and biological activity of a novel human neurotrophic factor
@nl
type
label
Primary structure and biological activity of a novel human neurotrophic factor
@ast
Primary structure and biological activity of a novel human neurotrophic factor
@en
Primary structure and biological activity of a novel human neurotrophic factor
@nl
prefLabel
Primary structure and biological activity of a novel human neurotrophic factor
@ast
Primary structure and biological activity of a novel human neurotrophic factor
@en
Primary structure and biological activity of a novel human neurotrophic factor
@nl
P2093
P1433
P1476
Primary structure and biological activity of a novel human neurotrophic factor
@en
P2093
A Rosenthal
D V Goeddel
G R Laramee
J W Winslow
K Nikolics
P304
P356
10.1016/0896-6273(90)90203-R
P407
P577
1990-05-01T00:00:00Z