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Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alphaTwo distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.Somatic mutations affect key pathways in lung adenocarcinomaH-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signalingIncreased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsiesOrigins, genetic landscape, and emerging therapies of small cell lung cancerPhosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancerThe determinants of head and neck cancer: Unmasking the PI3K pathway mutationsPTEN is a potent suppressor of small cell lung cancer.Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.Amplification of chromosomal segment 4q12 in non-small cell lung cancerA potential role for intragenic miRNAs on their hosts' interactome.Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapyOncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.Signaling mechanisms in neuroendocrine tumors as targets for therapy.The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenograftsKnockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.Pten signaling in gliomas.Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.Phosphatases: the new brakes for cancer development?Small cell lung cancer: from molecular biology to novel therapeutics.Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell CancerSmall cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer.Molecular pathology of non-small-cell lung cancer.Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomainsRecent progress in mouse models for tumor suppressor genes and its implications in human cancer.LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsTargeting the PI3-kinase/Akt/mTOR signaling pathway.Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cellsLiposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.Dysregulation of mTOR activity through LKB1 inactivation.Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors.Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung.Novel strategies for the treatment of small-cell lung carcinoma.The Biological Role of PI3K Pathway in Lung Cancer.Type III or allosteric kinase inhibitors for the treatment of non-small cell lung cancer.Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors.Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@ast
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@en
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@nl
type
label
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@ast
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@en
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@nl
prefLabel
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@ast
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@en
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@nl
P2093
P356
P1433
P1476
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
@en
P2093
A F Gazdar
E J Biesterveld
I I Wistuba
R Brezinschek
S Milchgrub
P2888
P304
P356
10.1038/SJ.ONC.1202070
P407
P577
1998-09-24T00:00:00Z
P5875
P6179
1011504438