Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
about
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationT cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceGlucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYNStructure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseasesRegulation of FynT function by dual domain docking on PAG/CbpIdentification of substrates of human protein-tyrosine phosphatase PTPN22Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signalingNore1B regulates TCR signaling via Ras and Carma1Aurora A drives early signalling and vesicle dynamics during T-cell activation.Role of actin dependent nuclear deformation in regulating early gene expressionStructural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic MacrocyclesNovel autophosphorylation sites of Src family kinases regulate kinase activity and SH2 domain-binding capacityNFAT proteins: key regulators of T-cell development and functionLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsLck availability during thymic selection determines the recognition specificity of the T cell repertoirePTPN22 1858C>T (R620W) functional polymorphism and human longevityThe protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functionsPhosphorylation site dynamics of early T-cell receptor signalingRegulation of T cell development by the deubiquitinating enzyme CYLDTwo-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationCD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infectionMolecular cloning and characterization of lymphocyte cell kinase from humphead snapper (Lutjanus sanguineus).Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity.Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri TipLck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsT cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.Proteomic characterization of plasma membrane-proximal T cell activation responses.Biophysical mechanism of T-cell receptor triggering in a reconstituted systemIntrinsic Photosensitivity Enhances Motility of T Lymphocytes.Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategyThe FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength
P2860
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P2860
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@ast
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@en
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@nl
type
label
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@ast
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@en
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@nl
prefLabel
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@ast
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@en
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@nl
P3181
P356
P1433
P1476
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
@en
P2093
Emil H Palacios
P2888
P304
P3181
P356
10.1038/SJ.ONC.1208074
P407
P50
P577
2004-10-18T00:00:00Z
P5875
P6179
1041178246