New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
about
Phosphorylation of microtubule-associated protein tau by AMPK-related kinasesGSPE interferes with tau aggregation in vivo: implication for treating tauopathyGlycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsCalcium/calmodulin-dependent kinase II and Alzheimer's diseaseTau-tubulin kinaseDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseCharacterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometryInvolvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3betaPhosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau proteinStructural polymorphism of 441-residue tau at single residue resolutionTau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tauOverexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neuronsThe tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39Detection and sequencing of phosphopeptides affinity bound to immobilized metal ion beads by matrix-assisted laser desorption/ionization mass spectrometry.Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells.Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.Characterization of the phosphorylation sites of the squid (Loligo pealei) high-molecular-weight neurofilament protein from giant axon axoplasm.Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy.Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylationFilamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.Mechanisms of tau-induced neurodegeneration.Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism.Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signalingPseudophosphorylation of tau protein directly modulates its aggregation kinetics.A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease.Drosophila models of neurodegenerative diseases.The role of DYRK1A in neurodegenerative diseases.Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein.Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual partsSoluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.Tyrosine nitration within the proline-rich region of Tau in Alzheimer's diseaseAlzheimer's disease: beta-Amyloid protein and tau.Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.Developing pharmacological therapies for Alzheimer disease.
P2860
Q24292882-0C257D34-6761-4E3B-89C0-DA01D3164687Q24628862-DB427382-7BA3-4DB4-A834-072065BBD30FQ24685475-C5C584E2-02E8-4AB3-8351-40ED71350ED5Q26776012-B5B6F48B-3F51-4AAF-BD07-F7238F7B1BF2Q26829288-04EDDAEA-A863-424A-A16C-E1DAB432CDBCQ26865654-D02BBA49-4B1D-426F-9852-02AC6A50170AQ28145739-B06107FF-B2D4-4935-A09B-B6B7571C0853Q28200189-57CB03EC-B089-4FED-A4E5-092ECC55595EQ28208444-E4FCABA5-F766-4D1B-B9EC-6B9FE84584DBQ28344418-8A563BE6-ED49-49BA-A2EA-4E5E3106C780Q28474834-96511929-F249-45E6-B529-2C8FBC561C59Q28504539-67CC7EA3-4606-4962-B854-EAC2A5BABBE2Q28537815-3DDCE52C-DCC3-473A-9A3B-E45D5D19FFD5Q28542476-82C31F3C-E29C-493B-AD71-C92AED2C2538Q28574229-42577CFC-4C64-45B1-BA3A-72A3B4D1F94BQ30856068-71686655-02E2-49AD-8B78-C5ADABCDF5C6Q30962853-7AAB536F-54AB-44CC-8DB6-65DE0FDDE4F5Q31111749-32A15D40-79EC-4429-BE0E-A1A33602758CQ31961843-93EC99C4-4A40-4DF6-8135-D4255E7A3A37Q33183604-7A8B686C-8F4D-42E3-AC29-C841A33F097FQ33224260-11D330F6-D586-45CA-849E-60EBE057973BQ33300947-DCB67C0D-7E46-42A0-B131-71C9B122FD60Q33703950-79C21895-4A77-4E09-9514-A46F448444AFQ33733724-BB2FFA75-C456-4997-8DCF-7EE94911A7FAQ33859830-DC8E10AD-48AA-4A57-A536-1D0F3D0B4253Q33921497-CA227135-9B85-4FF7-9310-69402C442D79Q34307528-AFEF021D-F521-40D8-AD6E-0CB5AB9EFB6CQ34405999-2DCDEB16-8176-4C19-A576-CAD8037BCF7EQ34411340-6C6F055B-4D7E-49D2-9409-497F40EE94B0Q34478697-37682C99-E23F-4B9A-9D18-E9106BDE8844Q34505264-B5674710-4F8A-4448-890C-12771060B425Q34610331-931E10E5-287F-4C51-BD93-79C0F6B08951Q34642120-AC69B7EC-5B6A-476A-A182-384759D95BF2Q34647932-9B3440E3-B4C2-4F46-AE20-185B2EDA0794Q34800214-E9C9B96C-05D8-49AC-B855-06CFA1180E4EQ34804911-DF9001FB-DC5C-4608-B031-C6A8E21763A5Q34838900-19860BA9-AEA9-4833-A900-A9F208B5076CQ34976291-D543875B-73D5-4496-B539-C1870AFE3EF7Q35000764-EE42B2D9-8A3B-412E-8AE0-2BA7879E46A1Q35114786-96A67AFE-4A01-4731-98F9-87FBEC2F5E59
P2860
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
New phosphorylation sites iden ...... electrospray mass spectrometry
@ast
New phosphorylation sites iden ...... electrospray mass spectrometry
@en
New phosphorylation sites iden ...... electrospray mass spectrometry
@nl
type
label
New phosphorylation sites iden ...... electrospray mass spectrometry
@ast
New phosphorylation sites iden ...... electrospray mass spectrometry
@en
New phosphorylation sites iden ...... electrospray mass spectrometry
@nl
prefLabel
New phosphorylation sites iden ...... electrospray mass spectrometry
@ast
New phosphorylation sites iden ...... electrospray mass spectrometry
@en
New phosphorylation sites iden ...... electrospray mass spectrometry
@nl
P2093
P921
P3181
P1476
New phosphorylation sites iden ...... electrospray mass spectrometry
@en
P2093
B H Anderton
D P Hanger
T L Loviny
W P Blackstock
P304
P3181
P356
10.1046/J.1471-4159.1998.71062465.X
P407
P50
P577
1998-12-01T00:00:00Z