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Atomic structure of thymidylate synthase: target for rational drug design

Atomic structure of thymidylate synthase: target for rational drug design

http://www.wikidata.org/entity/Q28290253

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Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency Application of biologically based computer modeling to simple or complex mixtures.Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex Crystal structure of thymidylate synthase A from Bacillus subtilis Biological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine Intracellular location of thymidylate synthase and its state of phosphorylation Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues.Local and spatial factors determining HIV-1 protease substrate recognition.Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases.Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer.Functional role of cysteine-146 in Escherichia coli thymidylate synthase.Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations.Inactivation of secretory phospholipase A2 by ionizing radiation.Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.Isolation and expression of the Pneumocystis carinii thymidylate synthase gene Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.Identification of in vivo target RNA sequences bound by thymidylate synthase.Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.Assembly reflects evolution of protein complexes Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase Cooperation between an intrinsically disordered region and a helical segment is required for ubiquitin-independent degradation by the proteasome Cloning and characterization of the thymidylate synthase gene from Lactococcus lactis subsp. lactis.Identification of an RNA binding site for human thymidylate synthase Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure Nucleotide metabolism and its control in lactic acid bacteria.Disulfide engineering at the dimer interface of Lactobacillus casei thymidylate synthase: crystal structure of the T155C/E188C/C244T mutant Regulation of p53 expression by thymidylate synthase

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P2860

Atomic structure of thymidylate synthase: target for rational drug design

http://www.wikidata.org/entity/Q28290253

description

1987 nî lūn-bûn

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1987 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1987 թվականի հունվարին հրատարակված գիտական հոդված

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1987年の論文

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1987年論文

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1987年論文

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1987年論文

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1987年論文

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1987年論文

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1987年论文

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name

Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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Atomic structure of thymidylate synthase: target for rational drug design

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D V Santi

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J S Finer-Moore

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L W Hardy

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