Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119
about
Receptors for acylethanolamides-GPR55 and GPR119Pharmacology and physiology of gastrointestinal enteroendocrine cellsA categorical structure-activity relationship analysis of GPR119 ligands.GPR119 agonists for the treatment of type 2 diabetesGPR109A and vascular inflammationHigh-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db miceN-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent MannerMolecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorderCurrent and future drug targets in weight managementDiscovery and characterization of novel small molecule agonists of G protein-coupled receptor 119.Free fatty acid receptors: emerging targets for treatment of diabetes and its complications.Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion.GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 releaseStructure-activity relationships of fatty acid amide ligands in activating and desensitizing G protein-coupled receptor 119.A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasisDiabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.Immunomodulation using agonists and antagonists: potential clinical applications.The therapeutic potential of GPR119 agonists for type 2 diabetes.Recent discovery of plant-derived anti-diabetic natural products.Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases?Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes.Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.Therapeutic application of GPR119 ligands in metabolic disorders.Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor.The incretin hormone GLP-1 and mechanisms underlying its secretion.The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119.GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanismsA conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.Parameterization of the GPR119 Receptor Agonist AR231453.Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes.GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity.
P2860
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P2860
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Discovery of the first potent ...... G-protein coupled receptor 119
@ast
Discovery of the first potent ...... G-protein coupled receptor 119
@en
Discovery of the first potent ...... G-protein coupled receptor 119
@nl
type
label
Discovery of the first potent ...... G-protein coupled receptor 119
@ast
Discovery of the first potent ...... G-protein coupled receptor 119
@en
Discovery of the first potent ...... G-protein coupled receptor 119
@nl
prefLabel
Discovery of the first potent ...... G-protein coupled receptor 119
@ast
Discovery of the first potent ...... G-protein coupled receptor 119
@en
Discovery of the first potent ...... G-protein coupled receptor 119
@nl
P2093
P356
P1476
Discovery of the first potent ...... G-protein coupled receptor 119
@en
P2093
Albert Ren
Andrew J Grottick
Beatriz Fioravanti
Charles Xing
Chris Carroll
David J Unett
Erin K Hauser
Graeme Semple
Guillherme Pereira
Imelda Calderon
P304
P356
10.1021/JM8006867
P407
P577
2008-09-11T00:00:00Z