Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion - Wikidata - awgldk - TriplyDB

Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion

Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion

http://www.wikidata.org/entity/Q28291461

about

Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism Interaction of ingested leucine with glycine on insulin and glucose concentrations Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.The role of leucine and its metabolites in protein and energy metabolism.Leucine and protein metabolism in obese Zucker rats.Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes.Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.Knowledge gained from studies of leucine consumption in animals and humans.The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications.Tuning the transcription and translation of L-amino acid deaminase in Escherichia coli improves α-ketoisocaproate production from L-leucine PWD/PhJ mice have a genetically determined increase in nutrient-stimulated insulin secretion.One-step biosynthesis of α-ketoisocaproate from L-leucine by an Escherichia coli whole-cell biocatalyst expressing an L-amino acid deaminase from Proteus vulgaris.Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner.SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.BCAA Metabolism and NH3 Homeostasis.

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P2860

Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion

http://www.wikidata.org/entity/Q28291461

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

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name

Transamination is required for ...... to stimulate insulin secretion

@ast

Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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type

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Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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Transamination is required for ...... to stimulate insulin secretion

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JBC.M110.136846

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Journal of Biological Chemistry

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Transamination is required for ...... to stimulate insulin secretion

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Christopher J Lynch

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Pengxiang She

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Stephanie Goshorn

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Thomas L Jetton

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Yingsheng Zhou

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P2860

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

TOR signaling in growth and metabolism

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion

Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance.

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.

Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.

The succinate mechanism of insulin release.

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.

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