GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions
about
Modulation of neuronal signal transduction and memory formation by synaptic zincInternational Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligandsZinc in the Glutamatergic Theory of DepressionThe Critical Roles of Zinc: Beyond Impact on Myocardial SignalingPharmacology and physiology of gastrointestinal enteroendocrine cellsGPR39 is coupled to TMEM16A in intestinal fibroblast-like cellsOverexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma.The role of brain-derived neurotrophic factor in comorbid depression: possible linkage with steroid hormones, cytokines, and nutritionGPR39 marks specific cells within the sebaceous gland and contributes to skin wound healingGPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampusChemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.Organ-specific adaptive signaling pathway activation in metastatic breast cancer cellsNovel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes.Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.Recent advances in pancreatic endocrine and exocrine secretion.Autocrine regulation of insulin secretion.Zinc and insulin in pancreatic beta-cells.Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.Zn(2+) at a cellular crossroads.GPR39 receptors and actions of trace metals on pancreatic beta cell function and glucose homoeostasis.The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function.Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).Autocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion.Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis.Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization.The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.Zinc in Cellular Regulation: The Nature and Significance of "Zinc Signals".Zinc and Skin Disorders.Transcriptional Alterations in the Trigeminal Ganglia, Nucleus and Peripheral Blood Mononuclear Cells in a Rat Orofacial Pain Model.
P2860
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P2860
GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions
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2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2011 թվականի հունվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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name
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@ast
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@en
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@nl
type
label
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@ast
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@en
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@nl
prefLabel
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@ast
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@en
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
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P1476
GPR39: a Zn(2+)-activated G pr ...... estinal and neuronal functions
@en
P2093
Alan J Stewart
Petra Popovics
P2860
P2888
P356
10.1007/S00018-010-0517-1
P407
P577
2011-01-01T00:00:00Z