High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections - Wikidata - awgldk - TriplyDB

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections

http://www.wikidata.org/entity/Q28292927

about

Antifungal testing and high-throughput screening of compound library against Geomyces destructans, the etiologic agent of geomycosis (WNS) in bats Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans ASDCD: antifungal synergistic drug combination database NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning Multicomponent therapeutics of berberine alkaloids Bioprospecting microbial natural product libraries from the marine environment for drug discovery.Chemogenomic profiling predicts antifungal synergies.In vitro synergistic effect of curcumin in combination with third generation cephalosporins against bacteria associated with infectious diarrhea.Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole Systematics-guided bioprospecting for bioactive microbial natural products.A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-tuberculosis activity.Optimization for the production of surfactin with a new synergistic antifungal activity.Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: natural thioether Michael addition adducts as antitubercular prodrugs.Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.Verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, Penicillium aurantiogriseum Endophytic Streptomyces sp. Y3111 from traditional Chinese medicine produced antitubercular pluramycins.Cloning and characterization of a novel 2-ketoisovalerate reductase from the beauvericin producer Fusarium proliferatum LF061.Three antimycobacterial metabolites identified from a marine-derived Streptomyces sp. MS100061.High-throughput nano-biofilm microarray for antifungal drug discovery Cloning and characterization of the gene cluster required for beauvericin biosynthesis in Fusarium proliferatum.Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.Mechanisms of antibiotic resistance.Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3) fluorescence.Systematic exploration of synergistic drug pairs.Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole.Quinazolin-4-one coupled with pyrrolidin-2-iminium alkaloids from marine-derived fungus Penicillium aurantiogriseum.Dual action antifungal small molecule modulates multidrug efflux and TOR signaling Antiplatelet effects of qishen yiqi dropping pill in platelets aggregation in hyperlipidemic rabbits.Novel short antimicrobial peptide isolated from Xenopus laevis skin.Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa.Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport Transcriptomics Analysis of Candida albicans Treated with Huanglian Jiedu Decoction Using RNA-seq.Quinone derivatives isolated from the endolichenic fungus Phialocephala fortinii are Mdr1 modulators that combat azole resistance in Candida albicans.Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System.Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.Combinatorial strategies for combating invasive fungal infections.

P2860

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P2860

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections

http://www.wikidata.org/entity/Q28292927

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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Chengzhang Fu

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Chuansen Zheng

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Gang Pei

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Guochun Zhou

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Haixiang Sun

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Huanqin Dai

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Jian Wang

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Jiang Bian

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Jianlan You

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Jintao Liu

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P2860

Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

Diversifying microbial natural products for drug discovery.

Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

Rationale for combination antifungal therapy.

Cell biology. A fungal Achilles' heel.

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

Resistance of Candida species to fluconazole

In vitro determination of optimal antifungal combinations against Cryptococcus neoformans and Candida albicans.

Effect of fluconazole on fungicidal activity of flucytosine in murine cryptococcal meningitis

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