Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation
about
The netrin protein familyCrystal structure of a hemojuvelin-binding fragment of neogenin at 1.8ÅN-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptorsStructures of netrin-1 bound to two receptors provide insight into its axon guidance mechanismSelective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogeninThe RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5cFLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neuronsMirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neuronsUNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.Interfering with multimerization of netrin-1 receptors triggers tumor cell death.SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.Neogenin may functionally substitute for Dcc in chicken.Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus.Netrin-5 is highly expressed in neurogenic regions of the adult brain.Induction of cardioprotection by small netrin-1-derived peptidesSignaling mechanism of the netrin-1 receptor DCC in axon guidance.Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila.Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.Netrins promote developmental and therapeutic angiogenesis.Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptorIdentification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.Potential therapeutics for myocardial ischemia-reperfusion injury. Focus on "Induction of cardioprotection by small netrin-1-derived peptides".Mutations in the netrin-1 gene cause congenital mirror movements.
P2860
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P2860
Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
@wuu
name
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@ast
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@en
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@nl
type
label
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@ast
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@en
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@nl
prefLabel
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@ast
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@en
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@nl
P2093
P1476
Mapping netrin receptor bindin ...... g its tyrosine phosphorylation
@en
P2093
Jeeyong Lee
Kun-Liang Guan
Robert P Kruger
Weiquan Li
P304
10826-10834
P356
10.1523/JNEUROSCI.3715-04.2004
P407
P577
2004-12-01T00:00:00Z