A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
about
Combining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biologyNicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.Chiral amine synthesis using ω-transaminases: an amine donor that displaces equilibria and enables high-throughput screening.New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates.Discovery and characterization of a putrescine oxidase from Rhodococcus erythropolis NCIMB 11540.Directed evolution of aldolases for exploitation in synthetic organic chemistryRecent biocatalytic oxidation-reduction cascades.Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger.Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds.Monoamine oxidase and transaminase screening: biotransformation of 2-methyl-6-alkylpiperidines by Neopestalotiopsis sp. CBMAI 2030Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.Synthesis of novel 5-alkyl/aryl/heteroaryl substituted diethyl 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates by aziridine ring expansion of 2-[(aziridin-1-yl)-1-alkyl/aryl/heteroaryl-methylene]malonic acid diethyl esters.A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines.Single-operation deracemization of 3H-indolines and tetrahydroquinolines enabled by phase separation.Development of dynamic kinetic resolution on large scale for (±)-1-phenylethylamine.The role of biocatalysis in the asymmetric synthesis of alkaloids.Dendron-anchored organocatalysts: the asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron.Kinetic mechanism of putrescine oxidase from Rhodococcus erythropolis.Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines.Chemoenzymatic synthesis of all four diastereomers of 2,6-disubstituted piperidines through stereoselective monoamination of 1,5-diketones.Rapid screening and scale-up of transaminase catalysed reactions.Synthesis of chiral cyclic amines via Ir-catalyzed enantioselective hydrogenation of cyclic imines.A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations.Organocatalytic Redox Deracemization of Cyclic Benzylic Ethers Enabled by An Acetal Pool Strategy.Immobilised whole-cell recombinant monoamine oxidase biocatalysis.Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network.Enantioselective, ketoreductase-based entry into pharmaceutical building blocks: ethanol as tunable nicotinamide reductant.Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-NDiscovery and Protein Engineering of Biocatalysts for Organic SynthesisBiocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral AminesDeracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variantsMonoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of AminesAsymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine ReductaseDirected Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine AOxidation of CN BondsBiocatalytic Routes to Nonracemic Chiral Amines
P2860
Q28833210-AD3ACCAA-BF65-4A8B-9A03-DE5E9045B198Q34067895-43D10F38-CDDA-4EA0-BB3B-96EE9415A23AQ35835835-BA0DF82F-621C-42FA-BACB-02B97774288BQ36006405-A1F15711-47E8-419E-8DB4-ECDD457CEAF0Q36460019-88927174-740B-4C3B-9190-B452D3D455FDQ37071273-C74C1F79-A94C-4567-BE52-EA8EB2915595Q37815710-8746B5C5-7F1E-48CF-AF41-1FB335ABF61EQ38272838-D7B9392F-BEF1-4B93-A78D-4418E1CC61C0Q41031429-0BD2E8E8-FCB6-4C41-A60B-354E26B62330Q41095114-2162427D-9312-4EFF-B5A7-6EB81D5A2371Q41125445-0451F8ED-551A-400D-8937-AAA802CBF819Q41812926-152D5000-BBDB-48DE-9926-80065EDF64FFQ41870013-114ACD3F-F30C-4251-8E97-60DB152350A3Q42234666-326BBA1D-2B75-4159-8D86-1923C6C75712Q42408821-0F47E556-C480-4149-B0DB-7A3813FEC4F0Q43092724-077A1F5A-D07E-4E03-9C17-40926EDE81CBQ43213874-12728C52-810C-49FE-8A8D-C48B29CC08F6Q44768727-FE117FBC-D7CA-4C1A-9D1C-CA41D803B062Q45408431-9251173F-59A4-4E06-89D7-75B12A510ACCQ46053696-1ACAD588-A332-4004-8C68-45FFCAAB1081Q46182856-B9584FDA-CBBF-4292-A508-12D20314BDE3Q48128110-962F8A6A-98A1-4C7A-A724-AC78F86D039AQ50224097-D88C06C4-F955-4CA7-8E56-A77CF2536C45Q50664212-C915B8C2-BC88-40FB-9890-E4AF88FDEA06Q53478426-8EED8153-644E-4B57-A998-4B71BB5349BEQ55407747-CBE64CD7-D6E8-405D-AB9B-000C9147B92DQ55426580-11D51BF4-66A0-4E64-9284-67AE42FDCA22Q56891246-A39C91DB-6460-4CE7-824A-36C0BAFC4DD3Q57189276-C4A8BA4E-58CD-4F23-A281-CC3AE3AEFF83Q58048600-F8934DE2-554F-431B-AD6F-8B672DC78108Q58048616-1851DDCB-D2A7-44C7-BBCA-43EC7AE67F03Q58048653-7779529E-0B3E-4788-A220-A038C1C77862Q58048676-408BD4D7-5740-43FF-9945-0302D1DCEFA9Q58048719-0B68D12E-32BA-4BB7-95B1-BB5CA21CEDEDQ58048722-901AEF02-529D-4DF8-8976-B6C4AD10CE1FQ58048763-66384520-4742-44DC-A915-B8CFBCB3DAA2
P2860
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@ast
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@en
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@nl
type
label
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@ast
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@en
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@nl
prefLabel
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@ast
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@en
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@nl
P2093
P3181
P356
P1476
A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines
@en
P2093
Colin J Dunsmore
Reuben Carr
Toni Fleming
P304
P3181
P356
10.1021/JA058536D
P407
P577
2006-02-22T00:00:00Z