Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew - Wikidata - awgldk - TriplyDB

Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

http://www.wikidata.org/entity/Q28300152

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Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase Scalable enantioselective total synthesis of taxanes Plant terpenoid synthases: molecular biology and phylogenetic analysis Studies on Taxol biosynthesis: preparation of taxadiene-diol and triol derivatives by deoxygenation of taxusin Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin Genomic organization of plant terpene synthases and molecular evolutionary implications Cytochrome P450 oxygenases of Taxol biosynthesis.Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis Taxol biosynthesis and molecular genetics Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew.Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin.Metabolic engineering of plant cells in a space environment.Chemical methods for the synthesis and modification of neoclerodane diterpenes Bioactive taxoids from the Japanese yew Taxus cuspidata.Engineering isoprenoid biosynthesis in Artemisia annua L. for the production of taxadiene: a key intermediate of taxol.Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway.The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites.Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli Identification of amino acid networks governing catalysis in the closed complex of class I terpene synthases.Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production.Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin.Downstream reactions and engineering in the microbially reconstituted pathway for Taxol.Chemical studies on Taxus canadensis.Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties Natural and engineered production of taxadiene with taxadiene synthase.Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene.Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest.Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases.Total synthesis of taxane terpenes: cyclase phase.Regio- and stereoselective hydroxylation of taxoids by filamentous fungi.Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess.Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol.Taxadiene-5α-ol is a minor product of CYP725A4 when expressed in Escherichia coli.Transcript profiling of jasmonate-elicited Taxus cells reveals a β-phenylalanine-CoA ligase.

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P2860

Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

http://www.wikidata.org/entity/Q28300152

description

1995 nî lūn-bûn

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1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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1995年の論文

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

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JBC.270.15.8686

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Journal of Biological Chemistry

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Cyclization of geranylgeranyl ...... ol biosynthesis in Pacific yew

@en

P2093

A E Koepp

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B S Vogel

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J Zajicek

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M Hezari

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N G Lewis

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R Croteau

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R E LaFever

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P2860

Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.

Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid.

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

The chemistry of taxol.

Taxol and derivatives: a biogenetic hypothesis.

The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents.

Initiation and growth of cell lines of Taxus brevifolia (Pacific yew).

Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species.

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.

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8686-90

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scholarly article

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10.1074/JBC.270.15.8686

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15

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270

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1995-04-14T00:00:00Z

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7721772

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