Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis
about
Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndromeLAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicityDefective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patientsThe molecular pathology of primary immunodeficienciesThe regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapseProtein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTLDifferences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome PatientsRegulated secretion from hemopoietic cells.Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse.Identification of the homologous beige and Chediak-Higashi syndrome genes.Centrosome docking at the immunological synapse is controlled by Lck signaling.Cytotoxic immunological synapses.Normal and abnormal secretion by haemopoietic cells.Lysosomes and the plasma membrane: trypanosomes reveal a secret relationshipDefective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel diseaseGenetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43.Expression and function of synaptotagmin VII in CTLsChediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.The cellular context of T cell signaling.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.Granzymes and caspase 3 play important roles in control of gammaherpesvirus latencyDefective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells.The biogenesis of lysosomes and lysosome-related organellesInsights into primary immune deficiency from quantitative microscopy.Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver.Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.Ypt4 and lvs1 regulate vacuolar size and function in Schizosaccharomyces pombeIdentification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense.Rab27a is required for regulated secretion in cytotoxic T lymphocytes.An actin cytoskeletal barrier inhibits lytic granule release from Natural Killer cells in Chediak-Higashi syndrome.
P2860
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P2860
Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@ast
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@en
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@nl
type
label
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@ast
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@en
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@nl
prefLabel
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@ast
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@en
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@nl
P921
P1476
Loss of cytotoxic T lymphocyte ...... vents lytic granule exocytosis
@en
P304
P407
P577
1995-06-01T00:00:00Z