Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
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The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesisMutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomasEGFR-TKI resistance in NSCLC patients: mechanisms and strategiesc-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF.Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.Molecular targeted therapy in advanced renal cell carcinoma: A review of its recent past and a glimpse into the near futureActivation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cellsMicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastomaMotif-guided sparse decomposition of gene expression data for regulatory module identification.JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signalingMUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasionStage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesisA pilot study of preoperative gefitinib for early-stage lung cancer to assess intratumor drug concentration and pathways mediating primary resistanceJAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.Adeno-associated virus vector mediated expression of an oncogenic retroviral envelope protein induces lung adenocarcinomas in immunocompetent mice.Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.STAT3 signaling: anticancer strategies and challenges.MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway.Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells.Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma.SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transitionInhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancerRole of STAT3 in lung cancer.Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening.Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid TumorsGenomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells.A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cellsInflammation and lung carcinogenesis: applying findings in prevention and treatment.
P2860
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P2860
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Signal transducer and activato ...... idermal growth factor receptor
@ast
Signal transducer and activato ...... idermal growth factor receptor
@en
Signal transducer and activato ...... idermal growth factor receptor
@nl
type
label
Signal transducer and activato ...... idermal growth factor receptor
@ast
Signal transducer and activato ...... idermal growth factor receptor
@en
Signal transducer and activato ...... idermal growth factor receptor
@nl
prefLabel
Signal transducer and activato ...... idermal growth factor receptor
@ast
Signal transducer and activato ...... idermal growth factor receptor
@en
Signal transducer and activato ...... idermal growth factor receptor
@nl
P2093
P1433
P1476
Signal transducer and activato ...... idermal growth factor receptor
@en
P2093
David A Frank
James V Alvarez
William R Sellers
P304
P356
10.1158/0008-5472.CAN-05-3757
P407
P577
2006-03-15T00:00:00Z