The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells
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Research gaps in defining the biological link between HIV risk and hormonal contraceptionThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapyRecent Insights into the HIV/AIDS Pandemic.Barriers to HIV Cure.Oral epithelial cells and their interactions with HIV-1.Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway.Humoral immune responses to HIV in the mucosal secretions and sera of HIV-infected women.Could vaccination with AIDSVAX immunogens have resulted in antibody-dependent enhancement of HIV infection in human subjects?Which Antibody Functions are Important for an HIV Vaccine?Interactions between HIV-1 and mucosal cells in the female reproductive tractThe role of Fc receptors in HIV infection and vaccine efficacy.Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccinesMABGEL 1: first phase 1 trial of the anti-HIV-1 monoclonal antibodies 2F5, 4E10 and 2G12 as a vaginal microbicideEnhanced in vitro transcytosis of simian immunodeficiency virus mediated by vaccine-induced antibody predicts transmitted/founder strain number after rectal challenge.Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.A High Throughput Protein Microarray Approach to Classify HIV Monoclonal Antibodies and Variant Antigens.Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex.Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRnRelease of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction.Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cellsIn men at risk of HIV infection, IgM, IgG1, IgG3, and IgA reach the human foreskin epidermis.Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel.The role of Fc receptors in HIV prevention and therapy.Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytesHuman immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease.Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection.Protein and oligonucleotide delivery systems for vaginal microbicides against viral STIs.Engineering broadly neutralizing antibodies for HIV prevention and therapy.Membrane Transport across Polarized Epithelia.Alteration of Polymeric Immunoglobulin Receptor and Neonatal Fc Receptor Expression in the Gut Mucosa of Immunodeficiency Virus-Infected Rhesus Macaques.Mucosal vaccination promotes clearance of Streptococcus agalactiae vaginal colonization.Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.Antibodies and Acidic Environment Do Not Enhance HIV-1 TranscytosisMedroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity.Conserved HIV Epitopes for an Effective HIV Vaccine.A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques.
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P2860
The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells
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The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@ast
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@en
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
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label
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@ast
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@en
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@nl
prefLabel
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@ast
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@en
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@nl
P2093
P2860
P50
P1433
P1476
The Neonatal Fc receptor (FcRn ...... ytosis across epithelial cells
@en
P2093
Brian Moldt
Davide Corti
Deborah J Anderson
Dennis R Burton
Donald N Forthal
Gary Landucci
Jeffrey Pudney
Jiri Mestecky
Juan C Becerra
Li-Hua Ping
P2860
P304
P356
10.1371/JOURNAL.PPAT.1003776
P407
P577
2013-01-01T00:00:00Z