Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4
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Identification of 80K-H as a protein involved in GLUT4 vesicle traffickingMunc18-syntaxin complexes and exocytosis in human plateletsA role for Sec1/Munc18 proteins in platelet exocytosisReduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathwayDOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytesPossible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formationThe Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complexSyntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cellsAnalysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membraneSyntaxin 4 heterozygous knockout mice develop muscle insulin resistanceNegative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitroMunc18c depletion selectively impairs the sustained phase of insulin releaseIdentification of a mammalian Golgi Sec1p-like protein, mVps45Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin actionAQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18bMunc-18-2 regulates exocytosis of H(+)-ATPase in rat inner medullary collecting duct cellsDirect interaction of Rab4 with syntaxin 4Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalizationCellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cellsPerturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes. Dynamin II participates in GLUT4 endocytosis.A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell.Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle.GLUT4--at the cross roads between membrane trafficking and signal transduction.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivityPantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles.GTP-binding proteins and regulated exocytosis.Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells.Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity.Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles.Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes.Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell linesStructure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins.VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif.Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosisMilligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures.
P2860
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P2860
Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@ast
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@en
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@nl
type
label
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@ast
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@en
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@nl
prefLabel
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@ast
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@en
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@nl
P2093
P356
P1476
Characterization of Munc-18c a ...... n-dependent movement of GLUT-4
@en
P2093
D R Hewish
J T Tellam
S L Macaulay
S McIntosh
P304
P356
10.1074/JBC.272.10.6179
P407
P577
1997-03-07T00:00:00Z