T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation
about
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-JunThe T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis.Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.Signal transduction molecules as targets for cancer prevention.T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.Phosphorylation of IκBα at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells.PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growthStable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colonCefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase.ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK.The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.T-LAK cell-originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC-7721 cells.TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer.Role of TOPK in lipopolysaccharide-induced breast cancer cell migration and invasion.Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinase.Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury.PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway.In silico structural and functional analysis of the human TOPK protein by structure modeling and molecular dynamics studies.Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.
P2860
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P2860
T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
T-lymphokine-activated killer ...... as-induced cell transformation
@ast
T-lymphokine-activated killer ...... as-induced cell transformation
@en
T-lymphokine-activated killer ...... as-induced cell transformation
@nl
type
label
T-lymphokine-activated killer ...... as-induced cell transformation
@ast
T-lymphokine-activated killer ...... as-induced cell transformation
@en
T-lymphokine-activated killer ...... as-induced cell transformation
@nl
prefLabel
T-lymphokine-activated killer ...... as-induced cell transformation
@ast
T-lymphokine-activated killer ...... as-induced cell transformation
@en
T-lymphokine-activated killer ...... as-induced cell transformation
@nl
P2093
P3181
P1433
P1476
T-lymphokine-activated killer ...... as-induced cell transformation
@en
P2093
Ann M Bode
Bong Seok Kang
Hong-Gyum Kim
Ki Won Lee
Sang-Muk Oh
Tatyana Zykova
Yong-Yeon Cho
Zigang Dong
P304
P3181
P356
10.1158/0008-5472.CAN-06-4506
P407
P577
2007-06-01T00:00:00Z