Sodium channels, inherited epilepsy, and antiepileptic drugs
about
Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryCellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channelsChanging channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitabilityDrosophila sodium channel mutations: Contributions to seizure-susceptibilityNav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodentsThe genetic relationship between epilepsy and hemiplegic migrainePharmacogenomics of cardiovascular complications in diabetes and obesity.Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plusMolecular biology of insect sodium channels and pyrethroid resistance.Lysine and the Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels.Three-dimensional modelling of the voltage-gated sodium ion channel from Anopheles gambiae reveals spatial clustering of evolutionarily conserved acidic residues at the extracellular sites.Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers.Biallelic SCN10A mutations in neuromuscular disease and epileptic encephalopathy.Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating.Choosing the safest acute therapy during chronic migraine prophylactic treatment: pharmacokinetic and pharmacodynamic considerations.Emerging roles of Na⁺/H⁺ exchangers in epilepsy and developmental brain disorders.Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders.Proteinases, Their Extracellular Targets, and Inflammatory Signaling.Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA/1 mouse model of SUDEP.5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome.A drug pocket at the lipid bilayer-potassium channel interface.Neurology--the next 10 years.Structural Models of Ligand-Bound Sodium Channels.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model of sudden unexpected death in epilepsy (SUDEP).A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility.Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents.A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line.PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity.Variants: Association With Cardiac DisordersPredicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin StudiesSelective Na1.1 activation rescues Dravet syndrome mice from seizures and premature death
P2860
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P2860
Sodium channels, inherited epilepsy, and antiepileptic drugs
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Sodium channels, inherited epilepsy, and antiepileptic drugs
@ast
Sodium channels, inherited epilepsy, and antiepileptic drugs
@en
Sodium channels, inherited epilepsy, and antiepileptic drugs
@nl
type
label
Sodium channels, inherited epilepsy, and antiepileptic drugs
@ast
Sodium channels, inherited epilepsy, and antiepileptic drugs
@en
Sodium channels, inherited epilepsy, and antiepileptic drugs
@nl
prefLabel
Sodium channels, inherited epilepsy, and antiepileptic drugs
@ast
Sodium channels, inherited epilepsy, and antiepileptic drugs
@en
Sodium channels, inherited epilepsy, and antiepileptic drugs
@nl
P3181
P1476
Sodium channels, inherited epilepsy, and antiepileptic drugs
@en
P2093
William A Catterall
P304
P3181
P356
10.1146/ANNUREV-PHARMTOX-011112-140232
P407
P577
2014-01-01T00:00:00Z