Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
about
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsChemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasisNew drug target in protozoan parasites: the role of thioredoxin reductaseMini review on tricyclic compounds as an inhibitor of trypanothione reductaseX-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolutionComparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruziStructure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeStructure and mechanism ofEscherichia coliglutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidasesA gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibitionInhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum ProliferationInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseStructural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthaseAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralogTrypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressLeishmanicidal metabolites from Cochliobolus sp., an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae)Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruziUntargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma bruceiStage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovaniDrug resistance in eukaryotic microorganisms.Glutathione.Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania majorStructural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data.Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.Transcriptome of Aphanomyces euteiches: new oomycete putative pathogenicity factors and metabolic pathwaysTrypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme.Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis."Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.Quiescin sulfhydryl oxidase from Trypanosoma brucei: catalytic activity and mechanism of a QSOX family member with a single thioredoxin domain.Molecular Docking and in Vitro Antileishmanial Evaluation of Chromene-2-thione Analogues.A Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major.Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductaseTrypanothione is the primary target for arsenical drugs against African trypanosomes.Parasitological and biochemical studies on cutaneous leishmaniasis in Shara'b District, Taiz, YemenThe parasite-specific trypanothione metabolism of trypanosoma and leishmania.Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.
P2860
Q24616801-41F526E8-815C-46A9-ADF3-5051CA38792FQ24649110-0404F3C2-4BEB-4188-A99C-AF00BF0E24D1Q24657204-0ED5F076-6AC9-42E2-BCAD-EE9EBAB0A452Q26781548-979D1CC9-81E9-4626-B5A4-0E74917A6918Q26852541-16E5C3CD-4E7D-46D7-BAFC-D94BB279F1D1Q27653946-3838AA1F-BAB2-43D7-B018-93CD7D9BC944Q27657406-4F69D1E3-927D-4006-AFC6-67B10C66ED91Q27658837-A7FE3D0E-1811-4BDE-B4A3-45DA8CCED56AQ27666555-5368BBCE-FAF9-4506-8941-5042FBC0AEBBQ27671675-0E5911B6-3C19-4C9E-8B8B-F3C5ADD23D45Q27684102-FC19D1AF-4932-49FF-BAF8-5EFB7CF29076Q27684748-9AC2A630-25FC-4645-8A15-CEEB4AAA91C8Q27690137-51D12E17-697D-4D7F-B7F0-36F389801152Q27702048-85321E91-E800-488C-9160-0D41A601FC93Q28119052-661F3245-78A5-4E59-833F-719C8F27E7A0Q28144631-EA4E2D9C-44DD-4479-82AA-D9D79A8C6C40Q28474272-A1FB89DB-42C4-4150-9AC8-90538B1DB170Q28474880-49045DE0-6798-47D5-8FF0-1D11832BA20DQ28483069-0A52B1E3-03CF-4FCB-B21B-FD61430DD752Q28539382-DE03FB92-3621-45F4-AFAF-1E466C8F7D1DQ30248243-432E17DD-9D20-4CD6-8177-2D8CCD13A743Q30412518-F7A51B4C-D4B3-415A-BDB7-63BE9EAD8EC8Q30443168-CD218542-B36D-4C6E-8EAC-0564EE627B2DQ31103011-A5A54148-833D-4E39-9E9E-8848BE1D1B20Q31142265-9C07876C-30F8-4935-AC79-C07A69D12383Q31148719-28B59FDB-AF0E-4E7A-98DD-BAACF5212B34Q32050441-B81DD552-9D70-4CB9-AD10-18307C1828A4Q33267859-EECA9AF4-5817-468B-A27F-43423AFA2144Q33419478-F76B727E-624A-4B5D-A797-678044E506ADQ33474992-444565BE-74E2-40CD-A1FA-1281021B0B0DQ33634169-15EDC6A1-B408-4178-8806-92080358A8EDQ33699199-73BEFA69-D5E5-4D8A-BF13-F2A6672D61F1Q33752764-97652C1B-4F76-4660-A799-ED0C339F0D6CQ33797941-C7282D30-C223-4980-92D4-EC46D8A8FD2AQ33806133-C0A7CDFA-EBA8-4D18-BBAA-F449672C9787Q33849836-639830C1-1DE8-4A7A-AC0A-0FA4ADEF3BCDQ33869978-BE9D159B-B18E-4526-8DF9-6CFFF2FEF3ABQ33966094-133F3CB3-6D25-47B2-A945-34C0273573C6Q34067320-128D6BCA-C634-49AA-9308-7390BFE40E73Q34097455-09710337-C881-4DF9-8D5F-496537C8464B
P2860
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
description
1985 nî lūn-bûn
@nan
1985 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի մարտին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@ast
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@en
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@nl
type
label
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@ast
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@en
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@nl
prefLabel
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@ast
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@en
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@nl
P2093
P3181
P356
P1433
P1476
Trypanothione: a novel bis(glu ...... e reductase in trypanosomatids
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.3883489
P407
P577
1985-03-22T00:00:00Z