Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency
about
Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cellsMottled Mice and Non-Mammalian Models of Menkes DiseaseMechanistic and regulatory aspects of intestinal iron absorptionMulti-copper oxidases and human iron metabolismMolecular mediators governing iron-copper interactionsIdentification of a Steap3 endosomal targeting motif essential for normal iron metabolismAnemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels.Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents.Inherited copper transport disorders: biochemical mechanisms, diagnosis, and treatment.Redox cycling in iron uptake, efflux, and traffickingHaemolysis and perturbations in the systemic iron metabolism of suckling, copper-deficient mosaic mutant mice - an animal model of Menkes disease.Effects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice.Desferrithiocin: a search for clinically effective iron chelators.Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases)Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake.Discovery of a cytosolic/soluble ferroxidase in rodent enterocytes.Rodent brain and heart catecholamine levels are altered by different models of copper deficiency.Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams.Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels.Metabolic crossroads of iron and copper.The gut in iron homeostasis: role of HIF-2 under normal and pathological conditionsMultiple mechanisms account for lower plasma iron in young copper deficient rats.Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium.Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunitiesNon-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS.G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin.Large scale expression and purification of secreted mouse hephaestin.Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis.Counteract of bone marrow of blotchy mice against the increases of plasma copper levels induced by high-fat diets in LDLR-/- mice.The Ferroxidase Hephaestin But Not Amyloid Precursor Protein is Required for Ferroportin-Supported Iron Efflux in Primary Hippocampal Neurons.
P2860
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P2860
Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Decreased hephaestin activity ...... auses systemic iron deficiency
@ast
Decreased hephaestin activity ...... auses systemic iron deficiency
@en
Decreased hephaestin activity ...... auses systemic iron deficiency
@nl
type
label
Decreased hephaestin activity ...... auses systemic iron deficiency
@ast
Decreased hephaestin activity ...... auses systemic iron deficiency
@en
Decreased hephaestin activity ...... auses systemic iron deficiency
@nl
prefLabel
Decreased hephaestin activity ...... auses systemic iron deficiency
@ast
Decreased hephaestin activity ...... auses systemic iron deficiency
@en
Decreased hephaestin activity ...... auses systemic iron deficiency
@nl
P2093
P356
P1433
P1476
Decreased hephaestin activity ...... auses systemic iron deficiency
@en
P2093
Andrew T McKie
Chris D Vulpe
Gang Huang
Huijun Chen
Zouhair K Attieh
P304
P356
10.1093/JN/136.5.1236
P407
P577
2006-05-01T00:00:00Z