Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome - Wikidata - awgldk - TriplyDB

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

http://www.wikidata.org/entity/Q28307704

about

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot Advances in Autophagy Regulatory Mechanisms Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance The neurology of mTOR The molecular basis for load-induced skeletal muscle hypertrophy Regulation of mTORC1 by PI3K signaling Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift Phosphoinositides: Key modulators of energy metabolism Regulation of mTORC1 by amino acids The expanding role of mTOR in cancer cell growth and proliferation Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.A lysosome-centered view of nutrient homeostasis Is REDD1 a Metabolic Éminence Grise?Beyond indigestion: emerging roles for lysosome-based signaling in human disease Sestrins inhibit mTORC1 kinase activation through the GATOR complex Sestrin2 is a leucine sensor for the mTORC1 pathway The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo mTOR signaling in tumorigenesis The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies Redox interplay between mitochondria and peroxisomes Compensatory Increase of Transglutaminase 2 Is Responsible for Resistance to mTOR Inhibitor Treatment Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development SZT2 dictates GATOR control of mTORC1 signalling.mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease.Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.Starved epithelial cells uptake extracellular matrix for survival.mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.

P2860

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P2860

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

http://www.wikidata.org/entity/Q28307704

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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type

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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prefLabel

Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

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J.CELL.2013.11.049

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Spatial control of the TSC com ...... tion of mTORC1 at the lysosome

@en

P2093

Alexander J Valvezan

http://www.w3.org/2001/XMLSchema#string

Brendan D Manning

http://www.w3.org/2001/XMLSchema#string

George Talbott

http://www.w3.org/2001/XMLSchema#string

Gerta Hoxhaj

http://www.w3.org/2001/XMLSchema#string

Hidenori Takahashi

http://www.w3.org/2001/XMLSchema#string

Suchithra Menon

http://www.w3.org/2001/XMLSchema#string

P2860

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

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771-85

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scholarly article

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907790

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10.1016/J.CELL.2013.11.049

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4

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156

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Lewis C. Cantley

Christian C. Dibble

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2014-02-13T00:00:00Z

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260217656

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24529379

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4030681

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