about
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complexStructural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexesActivation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domainsMechanisms of Hsp90 regulationThe 'active life' of Hsp90 complexesDihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactionsThe Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancerMolecular characterization of macbecin as an Hsp90 inhibitorOptimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitorsStructural basis of the radicicol resistance displayed by a fungal hsp90Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studiesStructural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity ReceptorsFeatures of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 InhibitorsTargeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studiesStructure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-Terminal α-7 Helix of the TPR Domain of AIP Is Sufficient for Pituitary Adenoma PredispositionSynthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperoneIdentification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperoneStructural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycinChaperone ligand-discrimination by the TPR-domain protein Tah1.A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progressionQri2/Nse4, a component of the essential Smc5/6 DNA repair complex.The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug bindingDynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machineThreonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activityCrystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complexDNA fragmentation-based combinatorial approaches to soluble protein expression Part I. Generating DNA fragment libraries.DNA fragmentation based combinatorial approaches to soluble protein expression Part II: library expression, screening and scale-up.Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Cloning of the HIS3 gene of Yarrowia lipolytica.Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
P50
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P50
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Chrisostomos Prodromou
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P106
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P31
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