about
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screeningProtein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthaseEvolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein designStructural Insights into the Ferroxidase Site of Ferritins from Higher EukaryotesThe structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolismTargeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivativesLoop electrostatics modulates the intersubunit interactions in ferritinIron binding to human heavy-chain ferritinProfiling of Flavonol Derivatives for the Development of Antitrypanosomatidic DrugsX-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitorsFerroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic CavityCrystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and ImipenemTime-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster.Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disordersAtomic-Resolution Structure of a Class C β-Lactamase and Its Complex with AvibactamStructural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS InhibitorsStructural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational VariabilitiesTargeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.Iron Biomineral Growth from the Initial Nucleation Seed in L-FerritinIdentification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein InteractionStructural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 InhibitorsDiscovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial InfectionsProbing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpartAccelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery PlatformEffect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritinVNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosaFibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the TerminiEnhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic InfectionsSAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection ModelHigh-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
P50
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P50
description
hulumtuese
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researcher
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ricercatrice
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wetenschapper
@nl
հետազոտող
@hy
name
Cecilia Pozzi
@ast
Cecilia Pozzi
@en
Cecilia Pozzi
@es
Cecilia Pozzi
@fr
Cecilia Pozzi
@nl
Cecilia Pozzi
@sl
type
label
Cecilia Pozzi
@ast
Cecilia Pozzi
@en
Cecilia Pozzi
@es
Cecilia Pozzi
@fr
Cecilia Pozzi
@nl
Cecilia Pozzi
@sl
prefLabel
Cecilia Pozzi
@ast
Cecilia Pozzi
@en
Cecilia Pozzi
@es
Cecilia Pozzi
@fr
Cecilia Pozzi
@nl
Cecilia Pozzi
@sl
P214
P1053
A-6246-2015
P106
P1153
48661323600
P21
P214
P31
P3829
P396
IT\ICCU\CFIV\271279
P496
0000-0003-2574-3911
P569
1983-01-01T00:00:00Z