Site-specific mutagenesis of AIDS virus reverse transcriptase
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The unusual nucleotide content of the HIV RNA genome results in a biased amino acid composition of HIV proteinsLamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsPolymerase structures and function: variations on a theme?Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptaseConservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmissionInfluence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domainsHIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide SubstrateIdentification of the human immunodeficiency virus reverse transcriptase residues that contribute to the activity of diverse nonnucleoside inhibitorsViral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitorsHP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNAses HChimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitorsIsolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptaseMutants of feline immunodeficiency virus resistant to 3'-azido-3'-deoxythymidineResumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidineComparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptasesInhibition of human immunodeficiency virus in vitro by combinations of 3'-azido-3'-deoxythymidine and foscarnetNovel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidineAlkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistanceNovel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolatesActivity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replicationAnti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptaseMapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step studyIdentification of four conserved motifs among the RNA-dependent polymerase encoding elementsA mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1.Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences.Retrotransposon-like nature of Tp1 elements: implications for the organisation of highly repetitive, hypermethylated DNA in the genome of Physarum polycephalum.Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase.A sensitive method for the identification of uncharacterized viruses related to known virus groups: hepadnavirus model system.RNA-induced changes in the activity of the endonuclease encoded by the R2 retrotransposable element.Construction and characterization of a temperature-sensitive human immunodeficiency virus type 1 reverse transcriptase mutantRole of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.Wild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidineNon-nucleoside reverse transcriptase inhibitors: the NNRTI boom.A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerizationLinker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain.The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity.
P2860
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P2860
Site-specific mutagenesis of AIDS virus reverse transcriptase
description
article publié dans la revue scientifique Nature
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artikull shkencor
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artículu científicu
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scientific article published in Nature
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wetenschappelijk artikel
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գիտական հոդված
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գիտական յօդուած
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name
Site-specific mutagenesis of AIDS virus reverse transcriptase
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Site-specific mutagenesis of AIDS virus reverse transcriptase
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Site-specific mutagenesis of AIDS virus reverse transcriptase
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type
label
Site-specific mutagenesis of AIDS virus reverse transcriptase
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Site-specific mutagenesis of AIDS virus reverse transcriptase
@en
Site-specific mutagenesis of AIDS virus reverse transcriptase
@nl
prefLabel
Site-specific mutagenesis of AIDS virus reverse transcriptase
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Site-specific mutagenesis of AIDS virus reverse transcriptase
@en
Site-specific mutagenesis of AIDS virus reverse transcriptase
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P2093
P356
P1433
P1476
Site-specific mutagenesis of AIDS virus reverse transcriptase
@en
P2093
P2888
P356
10.1038/327716A0
P407
P6179
1056438791