The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis
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The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteriaThe oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningMechanism of action of the oxazolidinone antibacterial agentsIn vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agentsOxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.Linezolid-dependent function and structure adaptation of ribosomes in a Staphylococcus epidermidis strain exhibiting linezolid dependence.Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.Linezolid for the treatment of resistant gram-positive cocci.Lack of pharmacokinetic interaction between linezolid and antacid in healthy volunteers.In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactionsMechanism of action of DuP 721: inhibition of an early event during initiation of protein synthesis.Pharmacokinetics of linezolid in subjects with renal dysfunctionOxazolidinone antibacterial agents: development of the clinical candidates eperezolid and linezolid.On the specificity of antibiotics targeting the large ribosomal subunit.Linezolid: a promising option in the treatment of Gram-positives.Ribosomes from an oxazolidinone-resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free transcription-translation assay.Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycinMechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compoundA pharmacokinetic evaluation of concomitant administration of linezolid and aztreonam.Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors.Development and characterization of a Pseudomonas aeruginosa in vitro coupled transcription-translation assay system for evaluation of translation inhibitors.Linezolid absolute bioavailability and the effect of food on oral bioavailability.Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.On the target of a novel class of antibiotics, oxazolidinones, active against multidrug-resistant Gram-positive bacteria.
P2860
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P2860
The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis
description
1988 nî lūn-bûn
@nan
1988 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
The mechanism of action of DuP ...... ts on macromolecular synthesis
@ast
The mechanism of action of DuP ...... ts on macromolecular synthesis
@en
The mechanism of action of DuP ...... ts on macromolecular synthesis
@nl
type
label
The mechanism of action of DuP ...... ts on macromolecular synthesis
@ast
The mechanism of action of DuP ...... ts on macromolecular synthesis
@en
The mechanism of action of DuP ...... ts on macromolecular synthesis
@nl
prefLabel
The mechanism of action of DuP ...... ts on macromolecular synthesis
@ast
The mechanism of action of DuP ...... ts on macromolecular synthesis
@en
The mechanism of action of DuP ...... ts on macromolecular synthesis
@nl
P2093
P1476
The mechanism of action of DuP ...... ts on macromolecular synthesis
@en
P2093
D C Eustice
P A Feldman
P304
P356
10.1016/0006-291X(88)90723-1
P407
P577
1988-02-15T00:00:00Z