Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry
about
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase CDifferential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands.Chemical genomics: massively parallel technologies for rapid lead identification and target validation.Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptorDesigning human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulatorsM1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory lossDevelopment of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsImmediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor.Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey.Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors.Pharmacological characterization of M1 muscarinic acetylcholine receptor-mediated Gq activation in rat cerebral cortical and hippocampal membranes.Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes.Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
P2860
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P2860
Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional comparison of musca ...... and hM5 using microphysiometry
@ast
Functional comparison of musca ...... and hM5 using microphysiometry
@en
Functional comparison of musca ...... and hM5 using microphysiometry
@nl
type
label
Functional comparison of musca ...... and hM5 using microphysiometry
@ast
Functional comparison of musca ...... and hM5 using microphysiometry
@en
Functional comparison of musca ...... and hM5 using microphysiometry
@nl
prefLabel
Functional comparison of musca ...... and hM5 using microphysiometry
@ast
Functional comparison of musca ...... and hM5 using microphysiometry
@en
Functional comparison of musca ...... and hM5 using microphysiometry
@nl
P2093
P2860
P356
P1476
Functional comparison of musca ...... and hM5 using microphysiometry
@en
P2093
A J Hunter
D N Middlemiss
J M Watson
K L Murkitt
P2860
P304
P356
10.1038/SJ.BJP.0702463
P407
P577
1999-04-01T00:00:00Z