5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
about
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MSThe organization and consequences of eicosanoid signalingLeukotrienes in pulmonary arterial hypertensionStructure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear exportConversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophilsCell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2FRET-based detection of different conformations of MK2.Sulphatides trigger polymorphonuclear granulocyte spreading on collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenaseEpstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase proteinMethyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosisERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsThe C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation.Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand bindingIntracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets.Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke.Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively.Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.Dimerization of human 5-lipoxygenase.Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenaseP66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats.Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells.The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity.Macrophage gene expression and foam cell formation are regulated by plasminogen.PPARalpha/gamma-Independent Effects of PPARalpha/gamma Ligands on Cysteinyl Leukotriene Production in Mast CellsERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthmaPhosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.5-Lipoxygenase: mechanisms of regulation.Phospholipid Ozonation Products Activate the 5-Lipoxygenase Pathway in Macrophages5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims.A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.Boswellic acids: a group of medicinally important compounds.Characterization of a novel MK3 splice variant from murine ventricular myocardium.5-Lipoxygenase inhibitors: a review of recent developments and patents.
P2860
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P2860
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@ast
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@en
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@nl
type
label
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@ast
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@en
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@nl
prefLabel
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@ast
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@en
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@nl
P2093
P2860
P356
P1476
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
@en
P2093
P2860
P304
P356
10.1073/PNAS.050588997
P407
P577
2000-05-09T00:00:00Z