Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents - Wikidata - awgldk - TriplyDB

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

http://www.wikidata.org/entity/Q28359877

about

Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newb A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*Antiviral drug discovery: ten more compounds, and ten more stories (part B).Inhibition of HIV-1 integrase by modified oligonucleotides derived from U5' LTR.Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.High-level resistance to 3'-azido-3'-deoxythimidine due to a deletion in the reverse transcriptase gene of human immunodeficiency virus type 1 Acyclic nucleoside phosphonates: a key class of antiviral drugs.Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients.Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.Antiviral therapy for human immunodeficiency virus infections Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication.The discovery of antiviral agents: ten different compounds, ten different stories.Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses.Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine Initial clinical experience with dideoxynucleosides as single agents and in combination therapy.Biochemical pharmacology of acyclic nucleotide analogues.Clinical applications of 3'-azido-2',3'-dideoxythymidine (AZT) and related dideoxynucleosides.Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.

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P2860

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

http://www.wikidata.org/entity/Q28359877

description

1988 nî lūn-bûn

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1988 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1988 թվականի հուլիսին հրատարակված գիտական հոդված

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1988年の論文

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1988年論文

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1988年論文

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1988年論文

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1988年論文

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1988年論文

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1988年论文

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Phosphonylmethoxyethyl purine ...... immunodeficiency virus agents

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Phosphonylmethoxyethyl purine ...... immunodeficiency virus agents

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Phosphonylmethoxyethyl purine ...... immunodeficiency virus agents

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Antimicrobial Agents and Chemotherapy

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Phosphonylmethoxyethyl purine ...... immunodeficiency virus agents

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A Holy

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D Schols

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P2860

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides

Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro

Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations.

Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.

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1025-30

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scholarly article

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10.1128/AAC.32.7.1025

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7

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