An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen - Wikidata - awgldk - TriplyDB

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

http://www.wikidata.org/entity/Q28361995

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Chemoprotection by phenolic antioxidants Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Blood gene expression profiling detects silica exposure and toxicity Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Induction of metallothionein l by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2 Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice Regulation of glutathione synthesis The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models Glutathione synthesis Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1 High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide Mechanistic studies of the Nrf2-Keap1 signaling pathway Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2 Regulation of Nrf2-an update Progress and prospects of reactive oxygen species in metal carcinogenesis

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P2860

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

http://www.wikidata.org/entity/Q28361995

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An important function of Nrf2 ...... etoxification of acetaminophen

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Proceedings of the National Academy of Sciences of the United States of America

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An important function of Nrf2 ...... etoxification of acetaminophen

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K Chan

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X D Han

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P2860

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Isolation of cDNA encoding the human NF-E2 protein

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

The "beta-like-globin" gene domain in human erythroid cells

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

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