Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis
about
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolTwo genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectivelyIdentification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive ratsSitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and managementMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskInactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male miceGenetic basis of sitosterolemiaHigh-resolution physical and transcript map of human chromosome 2p21 containing the sitosterolaemia locus.Phytosterolaemia in three unrelated South African families.ABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis.Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion.Genetic defenses against noncholesterol sterols.Protein mediators of sterol transport across intestinal brush border membrane.Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice.Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system.ABC transporters, atherosclerosis and inflammation.Lipid metabolism in bile acid malabsorption.Selective sterol accumulation in ABCG5/ABCG8-deficient mice.Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice.Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice.Phenotypic heterogeneity of sitosterolemia.Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.Phytosterolaemia: diagnosis, characterization and therapeutical approaches.Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited.Cholesterol supplementation with egg yolk increases plasma cholesterol and decreases plasma 7-dehydrocholesterol in Smith-Lemli-Opitz syndrome.Investigating Sitosterolemia to Understand Lipid Physiology.ABCG5 and ABCG8: more than a defense against xenosterols
P2860
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P2860
Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis
description
1986 nî lūn-bûn
@nan
1986 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
name
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@ast
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@en
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@nl
type
label
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@ast
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@en
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@nl
prefLabel
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@ast
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@en
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@nl
P2093
P2860
P3181
P356
P1476
Abnormal metabolism of shellfi ...... tosterolemia and xanthomatosis
@en
P2093
P2860
P304
P3181
P356
10.1172/JCI112513
P407
P577
1986-06-01T00:00:00Z