Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil
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Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability.Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality.Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects.Heterologous expression of human cytochrome P450 (CYP) 2C19 in Escherichia coli and establishment of RP-HPLC method to serve as activity marker.Maraviroc: in vitro assessment of drug-drug interaction potentialEffect of sildenafil citrate on intraocular pressure and blood pressure in human volunteers.Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance.Quality of drug information on the World Wide Web and strategies to improve pages with poor information quality. An intervention study on pages about sildenafil.Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertensionReverse-phase high-performance liquid chromatography for the simultaneous determination of sildenafil and N-desmethyl sildenafil in plasma of children.The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems.Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction.An opportunistic study evaluating pharmacokinetics of sildenafil for the treatment of pulmonary hypertension in infants.Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects.Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in miceADMET considerations for phosphodiesterase-5 inhibitors.Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment.CYP3A activity: towards dose adaptation to the individual.A Phase I study to assess the safety, tolerability and pharmacokinetic profile of boceprevir and sildenafil when dosed separately and together, in healthy male volunteers.Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports.Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil.Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation.The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers.Acute hemodynamic effects of single-dose sildenafil when added to established bosentan therapy in patients with pulmonary arterial hypertension: results of the COMPASS-1 study.The effects of cimetidine and antacid on the pharmacokinetic profile of sildenafil citrate in healthy male volunteers.Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.Increased cyclic guanosine monophosphate production and endothelial nitric oxide synthase level in mononuclear cells from sildenafil citrate-treated patients with erectile dysfunction.Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) maxim extract on the pharmacokinetics of sildenafil in rats.Metabolism of aildenafil in vivo in rats and in vitro in mouse, rat, dog, and human liver microsomes.Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.Identification of cytochrome P450 enzymes responsible for N -dealkylation of a new oral erectogenic, mirodenafil.Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.Prediction of clearance in humans from in vitro human liver microsomes and allometric scaling. A comparative study of the two approaches.Sildenafil vaginal suppositories: preparation, characterization, in vitro and in vivo evaluation.Evaluation of Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension.Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization.
P2860
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P2860
Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of the cytochro ...... N-demethylation of sildenafil
@ast
Identification of the cytochro ...... N-demethylation of sildenafil
@en
Identification of the cytochro ...... N-demethylation of sildenafil
@nl
type
label
Identification of the cytochro ...... N-demethylation of sildenafil
@ast
Identification of the cytochro ...... N-demethylation of sildenafil
@en
Identification of the cytochro ...... N-demethylation of sildenafil
@nl
prefLabel
Identification of the cytochro ...... N-demethylation of sildenafil
@ast
Identification of the cytochro ...... N-demethylation of sildenafil
@en
Identification of the cytochro ...... N-demethylation of sildenafil
@nl
P2093
P2860
P3181
P1476
Identification of the cytochro ...... N-demethylation of sildenafil
@en
P2093
P2860
P304
P3181
P356
10.1046/J.1365-2125.2001.00318.X
P407
P577
2001-03-01T00:00:00Z