Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein
about
Providing a molecular mechanism for P-glycoprotein; why would I bother?Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscsThe translocation mechanism of P-glycoprotein.The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motif.The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models.Detergent-free purification of ABC (ATP-binding-cassette) transporters.Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides.Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.
P2860
Q26777721-83F2B0CE-8574-4596-8019-83AB4542238CQ28536673-38484E26-C6E5-43BB-8286-D2BD98CB9898Q33257856-6364813D-253C-4B45-BDAF-EE5A78FAB5D9Q33802134-9747EC70-2175-46EB-B72F-7ECDAA723A70Q35012211-6709BE0A-35D8-4CF7-AB9F-73D04E8C3EDAQ36354417-9CB3EC2D-74E4-490F-8C16-E8E755DE7A97Q36835064-B22EF66D-8041-40CA-9831-56A8403086C6Q36966944-27FDE757-8F05-4E5E-92DF-2603F7D1AE7FQ37012424-5AA896DD-1A51-4406-A5CC-0932DF347107Q38347678-A323B813-2556-4D63-8AB1-22415D956E07Q38602443-21E916A4-9D94-484B-BD52-9AB2B1428A84Q39205029-2C89010B-4E38-421F-9E5E-BE4F5030327CQ39957087-63D049E2-0324-4DCF-AAAB-8DBA32752F9CQ40400095-A13BFAB8-CDA4-4E4C-B8E6-A4D770C01F7DQ40546719-2BAF96CC-5933-45E5-A981-1EE7977998B9Q41622487-C064F06D-E183-445D-A342-CCC4313911C7Q41828061-C3F04477-BDC6-4498-A8A4-0CBAD8E07437Q42105486-8101B41B-C539-4F15-9A20-26BDD97551F4Q42476085-EF714967-07C4-433D-98E0-E18EF0EAD916
P2860
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Detailed characterization of c ...... unction from wild-type protein
@ast
Detailed characterization of c ...... unction from wild-type protein
@en
Detailed characterization of c ...... unction from wild-type protein
@nl
type
label
Detailed characterization of c ...... unction from wild-type protein
@ast
Detailed characterization of c ...... unction from wild-type protein
@en
Detailed characterization of c ...... unction from wild-type protein
@nl
prefLabel
Detailed characterization of c ...... unction from wild-type protein
@ast
Detailed characterization of c ...... unction from wild-type protein
@en
Detailed characterization of c ...... unction from wild-type protein
@nl
P2093
P2860
P356
P1476
Detailed characterization of c ...... unction from wild-type protein
@en
P2093
A M Taylor
C F Higgins
J Woodhouse
K J Linton
L Soceneantu
R Callaghan
P2860
P304
P356
10.1038/SJ.BJP.0704400
P407
P577
2001-12-01T00:00:00Z