Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
about
Structural basis for androgen specificity and oestrogen synthesis in human aromataseThe structural biology of oestrogen metabolismBiosynthesis of cholesterol and other sterolsX-ray structure of human aromatase reveals an androgen-specific active siteKinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.Molecular cloning of a cDNA showing alternative splicing of the 5'-untranslated sequence of mRNA for human aromatase P-450.Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.Enzyme ingenuity in biological oxidations: a trail leading to cytochrome p450.Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase.Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant.Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.Nonsteroidal aromatase inhibitors: recent advances.Evidence for an elevated aspartate pK(a) in the active site of human aromataseCluster screening: an effective approach for probing the substrate space of uncharacterized cytochrome P450s.Coupled electron transfer and proton hopping in the final step of CYP19-catalyzed androgen aromatizationProximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anionModels and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis.Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.Characterization of a thiolato iron(III) Peroxy dianion complex.The ferrous-oxy complex of human aromataseSulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: role of the axial thiolate in reactivityRecent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice.Oxygen activation by cytochrome P450 monooxygenaseCatalytic strategy for carbon-carbon bond scission by the cytochrome P450 OleT.The critical iron-oxygen intermediate in human aromataseThe dual, opposing roles of estrogen in the prostate.Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n-1 aldehydes and alcohols in addition to alkanes.Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation19-Hydroxylation of androgens in the rat brain.Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step.Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase.Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms.Biochemical and molecular aspects of aromatase.Human aromatase: perspectives in biochemistry and biotechnology.An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.Conversion of 19-oxo[2 beta-2H]androgens into oestrogens by human placental aromatase. An unexpected stereochemical outcome.Enzymic aromatization of 6-alkyl-substituted androgens, potent competitive and mechanism-based inhibitors of aromatase.
P2860
Q24314572-BA08FFF3-96A3-4F8F-ABDA-677A4E5AB335Q27009283-9420D480-7D14-4190-A213-63FC083B95D4Q28744002-59AD386E-12EA-42BA-991D-AE7BC8727969Q33679045-2316E29C-FFF4-4B27-9B68-64A95A306C63Q33885255-9E7154B2-3298-4993-8BE2-53CD9B5456F4Q34061893-ABAC421E-8B11-46B4-89DA-BFD634D93C96Q34067102-2595FEAE-B68F-4C63-BF02-19AFC8A09A9DQ34131923-C3006564-6C64-4C58-9030-B85DF93EBB17Q34408176-B1FD0C87-1BA8-40ED-BEAD-D46CAC37978EQ34461803-ACC72647-031D-473B-9CD5-5BDF48C5212CQ34561176-464A7BFB-3A15-4408-8ABF-D467D5519622Q34587518-99EED1BD-D13F-4526-B054-138C44F75D4CQ34958506-EF8C2A51-149E-4334-AE75-ADF425C13BB0Q35014116-6BBBBD17-62C3-46F2-97EC-BB9199E1F95AQ35889886-E7F04C0B-A78D-44B2-B556-20C72AEBD64CQ35897516-FF0A2F05-4E80-4F4C-95CE-9A2B54F26DA5Q35961100-061F32DA-BE28-4E37-AFFA-24A7D013DD11Q36215989-56B50CB6-B66E-49F5-B327-C5D0015D0244Q36251699-6D82481B-00EE-47B1-B43C-D5066BBCE75EQ36782111-0BA20A62-B97B-4B43-A10B-A04EF503CE73Q36869531-E82BA479-E927-43C1-9DA3-4B7205C2F28FQ37025619-F6E018BB-D29C-4C2D-9F7C-D21409459558Q37202331-D2E1A079-EAAF-4A23-8BA6-ACD5AF798442Q37207087-AC97AA18-23CB-4487-90CD-F635626EB65DQ37247676-E7DB7305-A811-460C-AB4F-D9D2FDEA721EQ37366162-A5328497-0AAD-4856-A258-CA92A1004096Q37403654-533DA21A-0690-44A6-83B2-57EBAEA95DA1Q37520342-62681BD4-3E14-4F1C-9DE7-9EBF0DEA739DQ37600403-FD64C62E-EFAA-40BC-B2AE-BA65FF2EE418Q37604062-C22992EE-E0CA-4839-8163-FFB50D318965Q37685791-C72E3299-FBF1-4401-8E59-DCA79CE776A9Q37701442-F5CDF10C-7030-4CEF-B99A-A8BAB486B92CQ37739022-DF2625B5-96F0-4228-8713-087E040FFE40Q37784053-2D119FB9-5D02-4699-B286-2107A7CFF805Q37803635-EB70DC09-E53F-439B-ADEB-2CFA2FC6447DQ38099058-915E5EFD-7889-4984-A7E7-82C6449092A7Q38338517-5DD9F9A2-59A8-48E5-A62A-C6ECE23CB3D8Q41045769-B11671F4-E3FC-41E7-A876-015646B6F328Q41819790-3E9BCF14-4857-467A-BE35-FA5DC2B9FA31Q41931566-169A3537-D8DF-4F8C-BFF2-E39320D83F72
P2860
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
description
1982 nî lūn-bûn
@nan
1982 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1982 թվականի մարտին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年論文
@yue
1982年論文
@zh-hant
1982年論文
@zh-hk
1982年論文
@zh-mo
1982年論文
@zh-tw
1982年论文
@wuu
name
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@ast
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@en
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@nl
type
label
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@ast
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@en
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@nl
prefLabel
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@ast
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@en
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@nl
P2093
P2860
P356
P1433
P1476
Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
@en
P2093
P2860
P304
P356
10.1042/BJ2010569
P407
P577
1982-03-01T00:00:00Z