Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
about
DNA and the chromosome - varied targets for chemotherapyAlkylation of template strand of coding region causes effective gene silencingDNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugateGene targeting using zinc finger nucleasesGrowth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugateNext generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cellsCovalent stabilization of a small molecule-RNA complex.Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.A Bis(guanidinium)alcohol Attached to a Hairpin Polyamide: Synthesis, DNA Binding, and Plasmid Cleavage.Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cellsAlpha-diaminobutyric acid-linked hairpin polyamides.Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates.Covalent capture: merging covalent and noncovalent synthesis.Approaches to target the genome and its epigenome in cancer.Programmable DNA-binding small molecules.Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands.Comparative Analysis of DNA-Binding Selectivity of Hairpin and Cyclic Pyrrole-Imidazole Polyamides Based on Next-Generation Sequencing.Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates.Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites.Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core.Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity
P2860
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P2860
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@ast
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@en
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@nl
type
label
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@ast
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@en
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@nl
prefLabel
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@ast
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@en
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@nl
P1476
Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates
@en
P2093
P304
P356
10.1016/S1074-5521(00)00085-5
P407
P577
2000-03-01T00:00:00Z