Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies
about
Factors affecting drug-induced liver injury: antithyroid drugs as instances.Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5Asymmetric author-topic model for knowledge discovering of big data in toxicogenomics.Ameliorative effects of taurine against methimazole-induced cytotoxicity in isolated rat hepatocytes.Minimising the potential for metabolic activation in drug discovery.Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology.Nasal cytotoxic and carcinogenic activities of systemically distributed organic chemicals.Central role of mitochondria in drug-induced liver injury.Idiosyncratic reactions and metabolism of sulfur-containing drugs.An overview on the proposed mechanisms of antithyroid drugs-induced liver injury.Predicting organ toxicity using in vitro bioactivity data and chemical structure.Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine.Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic.Cytoprotective Effects of Organosulfur Compounds against Methimazole Induced Toxicity in Isolated Rat Hepatocytes.Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice.Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes.Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.Effect of selenium on methimazole-induced liver damage and oxidative stress in adult rats and their offspring.Carbonyl traps as potential protective agents against methimazole-induced liver injury.
P2860
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P2860
Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies
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2000 nî lūn-bûn
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2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
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2000年論文
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2000年論文
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name
Evidence for the involvement o ...... toxicity and metabolic studies
@ast
Evidence for the involvement o ...... toxicity and metabolic studies
@en
Evidence for the involvement o ...... toxicity and metabolic studies
@nl
type
label
Evidence for the involvement o ...... toxicity and metabolic studies
@ast
Evidence for the involvement o ...... toxicity and metabolic studies
@en
Evidence for the involvement o ...... toxicity and metabolic studies
@nl
prefLabel
Evidence for the involvement o ...... toxicity and metabolic studies
@ast
Evidence for the involvement o ...... toxicity and metabolic studies
@en
Evidence for the involvement o ...... toxicity and metabolic studies
@nl
P2093
P356
P1476
Evidence for the involvement o ...... toxicity and metabolic studies
@en
P2093
P356
10.1021/TX990155O
P407
P577
2000-03-01T00:00:00Z