Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
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Human engineered heart tissue as a versatile tool in basic research and preclinical toxicologySCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasisCell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndromeRescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channelsThe regulation of the cardiac potassium channel (HERG) by caveolin-1Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesAmiodarone inhibits apamin-sensitive potassium currentsMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainMolecular pathogenesis of long QT syndrome type 2Expression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heartPharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cellsInhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastineDifferences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndromeCorrection of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effectsInhibition of HERG potassium channels by celecoxib and its mechanismTrafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutationPharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and ThapsigarginIntegrated analysis of drug-induced gene expression profiles predicts novel hERG inhibitorsNew aspects of HERG K⁺ channel function depending upon cardiac spatial heterogeneityPronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbitsRegulation of an ERG K+ current by Src tyrosine kinaseFever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome.Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.Pentamidine reduces hERG expression to prolong the QT interval.HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1.Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium.Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncopeDrug-induced long QT syndrome in women.Electrophysiological Characteristics of the LQT2 Syndrome Mutation KCNH2-G572S and Regulation by Accessory Protein KCNE2.Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currentsPharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes.Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology.Selective molecular potassium channel blockade prevents atrial fibrillationEvaluation of the cardiac safety of second-generation antihistamines.Ceramide modulates HERG potassium channel gating by translocation into lipid rafts
P2860
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P2860
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Properties of HERG channels st ...... d at physiological temperature
@ast
Properties of HERG channels st ...... d at physiological temperature
@en
Properties of HERG channels st ...... d at physiological temperature
@nl
type
label
Properties of HERG channels st ...... d at physiological temperature
@ast
Properties of HERG channels st ...... d at physiological temperature
@en
Properties of HERG channels st ...... d at physiological temperature
@nl
prefLabel
Properties of HERG channels st ...... d at physiological temperature
@ast
Properties of HERG channels st ...... d at physiological temperature
@en
Properties of HERG channels st ...... d at physiological temperature
@nl
P2093
P2860
P3181
P1433
P1476
Properties of HERG channels st ...... d at physiological temperature
@en
P2093
C T January
G A Robertson
J C Makielski
P2860
P304
P3181
P356
10.1016/S0006-3495(98)77782-3
P407
P577
1998-01-01T00:00:00Z