Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators - Wikidata - awgldk - TriplyDB

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

http://www.wikidata.org/entity/Q28388871

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Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes Strategies for discovery of small molecule radiation protectors and radiation mitigators Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells Antioxidant Approaches to Management of Ionizing Irradiation Injury Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death.Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.Radiation mitigating properties of the lignan component in flaxseed GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines.Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network.Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice.Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice.Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice.Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice.Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma.Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics.Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency.Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039)

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Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

http://www.wikidata.org/entity/Q28388871

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2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Two strategies for the develop ...... le radiation damage mitigators

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Two strategies for the develop ...... le radiation damage mitigators

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Two strategies for the develop ...... le radiation damage mitigators

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Two strategies for the develop ...... le radiation damage mitigators

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J.IJROBP.2011.01.059

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International Journal of Radiation Oncology Biology Physics

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Two strategies for the develop ...... le radiation damage mitigators

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Alexander Doemling

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Barbara Beck

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Darcy Franicola

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Donna Shields

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Hong Wang

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Jean-Claude M Rwigema

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Joel S Greenberger

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Marie-Céline Frantz

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Tracy Dixon

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Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

Cancer. p53, guardian of the genome

A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator.

Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides.

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

Potassium softens vascular endothelium and increases nitric oxide release.

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3

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Michael W Epperly

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2011-07-01T00:00:00Z

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21493014

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