Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase - Wikidata - awgldk - TriplyDB

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

http://www.wikidata.org/entity/Q28392677

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p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy NF-κB, the first quarter-century: remarkable progress and outstanding questions Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer Implication of inflammatory signaling pathways in obesity-induced insulin resistance Quantitative modeling of dose–response and drug combination based on pathway network NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma Cot/tpl2 participates in the activation of macrophages by adiponectin.The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.TPL2 kinase regulates the inflammatory milieu of the myeloma niche TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling.Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitis Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages.Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination.Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.IκB kinase regulation of the TPL-2/ERK MAPK pathway.New insight into the oncogenic mechanism of the retroviral oncoprotein Tax.Tpl2 promotes innate cell recruitment and effector T cell differentiation to limit Citrobacter rodentium burden and dissemination.TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.Insights into the inhibition and mechanism of compounds against LPS-induced PGE2 production: a pathway network-based approach and molecular dynamics simulations.Physical and functional interaction of the TPL2 kinase with nucleophosmin.Separation of zinc-dependent and zinc-independent events during early LPS-stimulated TLR4 signaling in macrophage cells.IL-17 Signaling: The Yin and the Yang.Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.

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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

http://www.wikidata.org/entity/Q28392677

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@ast

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@en

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@nl

type

label

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@ast

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@en

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@nl

prefLabel

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@ast

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@en

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@nl

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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

@en

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Srividya Sriskantharajah

http://www.w3.org/2001/XMLSchema#string

Steven C Ley

http://www.w3.org/2001/XMLSchema#string

Thorsten Gantke

http://www.w3.org/2001/XMLSchema#string

P2860

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

Mutational activation of the MAP3K8 protooncogene in lung cancer

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

Structure and transforming potential of the human cot oncogene encoding a putative protein kinase

The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.

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131-45

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scholarly article

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2302283

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10.1038/CR.2010.173

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1

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21

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2011-01-01T00:00:00Z

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21135874

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3193413

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