about
The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative StressPromising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer.Key Targets for Multi-Target Ligands Designed to Combat NeurodegenerationAstrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathioneSmoking, psychiatric illness and the brain.Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.Pathways for small molecule delivery to the central nervous system across the blood-brain barrier.Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorderMonocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells.The cytochrome P450 2D-mediated formation of serotonin from 5-methoxytryptamine in the brain in vivo: a microdialysis study.Modulation of the genome and epigenome of individuals susceptible to autism by environmental risk factorsSubacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit.Acute, transitional and long-term cluster headache treatment: pharmacokinetic issues.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Personalized medicine in psychiatry.Microsomal cytochrome P450 as a target for drug discovery and repurposing.Differences in the expression and sensitivity of cultured rat brain neuronal and glial cells toward the monocrotophos.In situ hybridization study of CYP2D mRNA in the common marmoset brainRat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria.CYP2D6 ultra-rapid metabolizer phenotype not associated with attempted suicide in a large sample of psychiatric inpatients.Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.Polymorphic expression of CYP2C19 and CYP2D6 in the developing and adult human brain causing variability in cognition, risk for depression and suicide: the search for the endogenous substrates.Distribution of venlafaxine, O-desmethylvenlafaxine, and O-desmethylvenlafaxine to venlafaxine ratio in postmortem human brain tissue.Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine.Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats.Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain.Advancing psychiatric pharmacogenomics using drug development paradigms.CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Cytochrome P450-mediated drug metabolism in the brain
@ast
Cytochrome P450-mediated drug metabolism in the brain
@en
Cytochrome P450-mediated drug metabolism in the brain
@nl
type
label
Cytochrome P450-mediated drug metabolism in the brain
@ast
Cytochrome P450-mediated drug metabolism in the brain
@en
Cytochrome P450-mediated drug metabolism in the brain
@nl
prefLabel
Cytochrome P450-mediated drug metabolism in the brain
@ast
Cytochrome P450-mediated drug metabolism in the brain
@en
Cytochrome P450-mediated drug metabolism in the brain
@nl
P2860
P3181
P356
P1476
Cytochrome P450-mediated drug metabolism in the brain
@en
P2093
Sharon Miksys
P2860
P304
P3181
P356
10.1503/JPN.120133
P407
P577
2013-05-01T00:00:00Z