Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis
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An enzymatic atavist revealed in dual pathways for water activationDeciphering the genetic basis for polyketide variation among mycobacteria producing mycolactonesA computational screen for type I polyketide synthases in metagenomics shotgun dataAn Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of BacteriaThe origins of specificity in polyketide synthase protein interactions.Computational identification and analysis of orphan assembly-line polyketide synthases.Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteriaInterpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplificationMetamorphic enzyme assembly in polyketide diversification.Cryptic polyketide synthase genes in non-pathogenic Clostridium SPPPhylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.Genomic basis for natural product biosynthetic diversity in the actinomycetesArchitectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseA systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesisPhylogenetic approaches to natural product structure predictionA computationally simplistic poly-phasic approach to explore microbial communities from the Yucatan aquifer as a potential sources of novel natural products.Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters.The evolution of gene collectives: How natural selection drives chemical innovation.Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases.Emergent gene order in a model of modular polyketide synthases.Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics.The structures of type I polyketide synthases.Evolutionary concepts in natural products discovery: what actinomycetes have taught us.Biosynthesis of polyketides by trans-AT polyketide synthases.The evolution of genome mining in microbes - a review.Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488.Polyketide synthase gene diversity within the microbiome of the sponge Arenosclera brasiliensis, endemic to the Southern Atlantic Ocean.ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures.Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases.Significance of Heavy-Ion Beam Irradiation-Induced Avermectin B1a Production by Engineered Streptomyces avermitilis.Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line.Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.Intrageneric diversity of type-I ketosynthase domain genes in the genus Nocardia.Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
P2860
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P2860
Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis
description
2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@ast
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@en
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@nl
type
label
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@ast
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@en
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@nl
prefLabel
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@ast
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@en
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@nl
P2860
P3181
P1476
Natural biocombinatorics in th ...... erium Streptomyces avermitilis
@en
P2093
Holger Jenke-Kodama
Thomas Börner
P2860
P3181
P356
10.1371/JOURNAL.PCBI.0020132
P407
P577
2006-10-06T00:00:00Z