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Genetic determinants of human health span and life span: progress and new opportunities

Genetic determinants of human health span and life span: progress and new opportunities

http://www.wikidata.org/entity/Q28469271

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Developmental Drift and the Role of Wnt Signaling in Aging How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging "Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS).Mood, memory and movement: an age-related neurodegenerative complex?Gender-specific DNA methylome analysis of a Han Chinese longevity population Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review.High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism.Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.Aging in America in the twenty-first century: demographic forecasts from the MacArthur Foundation Research Network on an Aging Society.Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.Contemporary human genetic strategies in aging research.Progress & prospects: gene therapy in aging.Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.Subjective wellbeing and longevity: a co-twin control study.Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction.Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort Aging and stress: past hypotheses, present approaches and perspectives Aging genetics and aging.Less functional variants of TLR-1/-6/-10 genes are associated with age Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects.Are centenarians genetically predisposed to lower disease risk?Asynchrony of senescence among phenotypic traits in a wild mammal population.How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Genomics of human health and aging Inter-chromosomal level of genome organization and longevity-related phenotypes in humans New model of health promotion and disease prevention for the 21st century.Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children DRD4 genotype predicts longevity in mouse and human.Unraveling genetic origin of aging-related traits: evolving concepts Health-related phenotypes and longevity in danish twins The epidemiology of human telomeres: faults and promises.Association of the K153R polymorphism in the myostatin gene and extreme longevity.Toward a systems biology framework for understanding aging and health span.From cellular senescence to age-associated diseases: the miRNA connection.Substantial health and economic returns from delayed aging may warrant a new focus for medical research.Mutation and the evolution of ageing: from biometrics to system genetics.The search for evolutionary developmental origins of aging in zebrafish: a novel intersection of developmental and senescence biology in the zebrafish model system.

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Genetic determinants of human health span and life span: progress and new opportunities

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Genetic determinants of human health span and life span: progress and new opportunities

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Forces shaping the fastest evolving regions in the human genome

Lipoprotein genotype and conserved pathway for exceptional longevity in humans

An RNA gene expressed during cortical development evolved rapidly in humans

A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

Epigenetic differences arise during the lifetime of monozygotic twins

Susceptibility genes for age-related maculopathy on chromosome 10q26.

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Lamin A-dependent nuclear defects in human aging

Evolution at two levels in humans and chimpanzees

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