Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria
about
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisA new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatisSynthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analoguesS-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferasesInhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membraneMycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosisA Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos.The structure-activity relationship of urea derivatives as anti-tuberculosis agents.The mycobacterial cell envelope-lipidsDetection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen.Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosisExposure of mycobacteria to cell wall-inhibitory drugs decreases production of arabinoglycerolipid related to Mycolyl-arabinogalactan-peptidoglycan metabolism.In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatmentNew approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazoneWorld Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: unclear efficacy or untapped potential?Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulentNew drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.Nucleoside analogs and tuberculosis: new weapons against an old enemy.Tailored-pharmacophore model to enhance virtual screening and drug discovery: a case study on the identification of potential inhibitors against drug-resistant Mycobacterium tuberculosis (3R)-hydroxyacyl-ACP dehydratases.Synthesis and evaluation of new fluorinated anti-tubercular compoundsMycobacterial cell wall biosynthesis: a multifaceted antibiotic target.Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.Isoniazid and thioacetazone may exhibit antitubercular activity by binding directly with the active site of mycolic acid cyclopropane synthase: Hypothesis based on computational analysis.Synthesis and Antimycobacterial Activity of Symmetric Thiocarbohydrazone Derivatives against Mycobacterium bovis BCG.Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosisTemperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-mycolates.Preclinical pharmacokinetics of KBF611, a new antituberculosis agent in mice and rabbits, and comparison with thiacetazone.Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance.Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment
P2860
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P2860
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@ast
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@en
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@nl
type
label
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@ast
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@en
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@nl
prefLabel
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@ast
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@en
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@nl
P2093
P2860
P50
P1433
P1476
Thiacetazone, an antitubercula ...... mycolic acids in mycobacteria
@en
P2093
Anuradha Alahari
Geoffrey D Coxon
James C Sacchettini
Robert C Reynolds
Xavier Trivelli
P2860
P356
10.1371/JOURNAL.PONE.0001343
P407
P577
2007-12-19T00:00:00Z